The functioning side of the pancreas: a review on insulinomas.
Functioning neuroendocrine tumors
Hypoglycemia
Insulinoma
Neuroendocrine tumors
Pancreas
Journal
Journal of endocrinological investigation
ISSN: 1720-8386
Titre abrégé: J Endocrinol Invest
Pays: Italy
ID NLM: 7806594
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
18
04
2019
accepted:
24
07
2019
pubmed:
2
8
2019
medline:
6
11
2020
entrez:
2
8
2019
Statut:
ppublish
Résumé
Insulinomas are a rare type of neuroendocrine tumors, originating in the pancreas, difficult to diagnose and to treat. Due to its rarity, insulinomas are a not well-known pathological entity; thus, the diagnostic process is frequently a medical challenge with many possible differential diagnoses. The diagnostic process varies between non-invasive procedures, such as the fasting test or imaging techniques, and invasive ones. Insulinomas are rarely malignant, but the glycemic imbalance correlated with this tumor can frequently alter the quality of life of the patients and the consequent hypoglycemia can be extremely dangerous. Moreover, insulinomas can be associated with different genetic syndromes, such as Multiple Endocrine Neoplasia 1, accompanied by other specific symptoms. There are many different treatment strategies, depending on the need to control symptoms or control diseases progression, the only curative one being surgery. We reviewed the evidences present in the literature on insulinomas and reported its main clinical characteristics and management strategies. The aim of this review of the literature is to present the current knowledge on insulinomas, exploring the main clinical characteristics, the diagnostic tools, and the therapeutic strategies.
Identifiants
pubmed: 31368049
doi: 10.1007/s40618-019-01091-w
pii: 10.1007/s40618-019-01091-w
doi:
Substances chimiques
Receptors, Somatostatin
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
139-148Références
J Clin Oncol. 2004 Dec 1;22(23):4762-71
pubmed: 15570077
Gastroenterology. 2008 Nov;135(5):1469-92
pubmed: 18703061
Eur J Nucl Med Mol Imaging. 2018 Dec;45(13):2318-2327
pubmed: 30054698
J Nucl Med. 2011 Jul;52(7):1073-8
pubmed: 21680696
Adv Ther. 2012 Oct;29(10):864-73
pubmed: 23054693
J Clin Endocrinol Metab. 2017 Jan 1;102(1):195-199
pubmed: 27805844
World J Gastroenterol. 2008 Feb 7;14(5):657-65
pubmed: 18205253
Clin Genet. 2012 Dec;82(6):558-63
pubmed: 22035404
J Clin Endocrinol Metab. 2019 Apr 1;104(4):1336-1344
pubmed: 30566620
Hormones (Athens). 2016 Apr;15(2):271-276
pubmed: 26732164
Lancet. 2016 Mar 5;387(10022):968-977
pubmed: 26703889
Am J Surg Pathol. 2006 Aug;30(8):1047-51
pubmed: 16861979
Gastroenterology. 1988 Nov;95(5):1364-74
pubmed: 3139487
Cancer. 2011 Jan 15;117(2):268-75
pubmed: 20824724
J Clin Oncol. 2017 Jan 20;35(3):274-280
pubmed: 27646952
Ann Intern Med. 1995 Aug 15;123(4):269-73
pubmed: 7611592
J Clin Oncol. 2008 Jun 20;26(18):3063-72
pubmed: 18565894
Eur J Endocrinol. 2010 May;162(5):1001-8
pubmed: 20164213
Ann Surg Oncol. 2007 Jul;14(7):2121-7
pubmed: 17431724
J Hepatobiliary Pancreat Sci. 2019 Sep;26(9):383-392
pubmed: 31211879
Endocr Pathol. 2007 Summer;18(2):79-85
pubmed: 17916997
Neuroendocrinology. 2016;103(2):153-71
pubmed: 26742109
J Clin Endocrinol Metab. 2009 Sep;94(9):3157-62
pubmed: 19567519
Clin Cancer Res. 2009 Jan 1;15(1):338-45
pubmed: 19118063
Endocrine. 2018 Jun;60(3):490-498
pubmed: 29150792
Cancer. 1991 Jul 15;68(2):227-32
pubmed: 1712661
Neuroendocrinology. 2017;104(1):85-93
pubmed: 26943788
Gastroenterol Hepatol (N Y). 2010 Aug;6(8):520-2
pubmed: 20978556
Gastroenterol Res Pract. 2017;2017:7872519
pubmed: 29213282
Lancet Diabetes Endocrinol. 2013 Oct;1(2):115-22
pubmed: 24622317
Cancer. 1989 Jul 15;64(2):460-5
pubmed: 2544252
Nat Clin Pract Endocrinol Metab. 2007 Mar;3(3):228-39
pubmed: 17315031
Q J Nucl Med Mol Imaging. 2016 Mar;60(1):69-76
pubmed: 24740163
Pancreas. 2019 Jan;48(1):55-59
pubmed: 30451800
N Engl J Med. 2011 Feb 10;364(6):514-23
pubmed: 21306238
J Endocr Soc. 2018 May 22;2(7):589-596
pubmed: 29942923
Jpn J Clin Oncol. 2014 Feb;44(2):186-90
pubmed: 24367043
J Clin Endocrinol Metab. 2009 Mar;94(3):709-28
pubmed: 19088155
World J Gastrointest Endosc. 2015 Nov 10;7(16):1197-207
pubmed: 26566426
Front Endocrinol (Lausanne). 2012 Dec 06;3:158
pubmed: 23230431
Endocr Connect. 2017 Oct;6(7):540-548
pubmed: 28784625
J Nucl Med. 2016 May;57(5):715-20
pubmed: 26795291
Neth J Med. 1989 Aug;35(1-2):86-94
pubmed: 2550827
Pancreas. 2010 Aug;39(6):735-52
pubmed: 20664472
J Clin Endocrinol Metab. 2011 Nov;96(11):3381-9
pubmed: 21917872
AJR Am J Roentgenol. 2003 Oct;181(4):987-92
pubmed: 14500214
Postgrad Med J. 1995 Aug;71(838):485-6
pubmed: 7567757
Endocr J. 2019 Feb 28;66(2):149-155
pubmed: 30504655
Eur J Radiol. 2011 Dec;80(3):675-80
pubmed: 20965676
Cancer. 2008 Oct 1;113(7 Suppl):1807-43
pubmed: 18798544
AJNR Am J Neuroradiol. 1995 Aug;16(7):1543-4
pubmed: 7484652
Best Pract Res Clin Endocrinol Metab. 2007 Mar;21(1):33-41
pubmed: 17382264
Clin Cancer Res. 2017 Aug 15;23(16):4617-4624
pubmed: 28428192
Clin Nucl Med. 2015 Feb;40(2):e132-3
pubmed: 24830876
J Clin Endocrinol Metab. 2009 Apr;94(4):1074-80
pubmed: 19190102
Ann Surg Oncol. 2010 Sep;17(9):2427-43
pubmed: 20217257
Gastrointest Endosc. 2016 Jan;83(1):234-9
pubmed: 26394384
Eur J Endocrinol. 2017 Jul;177(1):R37-R47
pubmed: 28381450
Neuroendocrinology. 2016;103(2):172-85
pubmed: 26731013
Best Pract Res Clin Gastroenterol. 2005 Oct;19(5):753-81
pubmed: 16253899
Surg Clin North Am. 2009 Oct;89(5):1105-21
pubmed: 19836487
Eur J Gastroenterol Hepatol. 2015 May;27(5):527-35
pubmed: 25822862
J Clin Endocrinol Metab. 2009 Apr;94(4):1069-73
pubmed: 19141587
World J Surg. 2007 Mar;31(3):586-92
pubmed: 17322973
Cancer Imaging. 2004 Mar 29;4(2):84-91
pubmed: 18250013
J Natl Cancer Inst. 2012 May 16;104(10):764-77
pubmed: 22525418
Eur J Nucl Med Mol Imaging. 2015 Mar;42(3):531-2
pubmed: 25398421
Gastroenterol Clin Biol. 1997;21(4):343
pubmed: 9208005
J Clin Oncol. 2011 Jun 10;29(17):2372-7
pubmed: 21555696
Virchows Arch. 2006 Oct;449(4):395-401
pubmed: 16967267
Semin Oncol. 2010 Dec;37(6):594-618
pubmed: 21167379
Eur J Endocrinol. 2013 Apr 15;168(5):665-74
pubmed: 23392213
Mod Pathol. 2015 Jan;28(1):69-79
pubmed: 24947143
Best Pract Res Clin Gastroenterol. 2005 Oct;19(5):819-30
pubmed: 16253903
N Engl J Med. 2009 Jan 8;360(2):195-7
pubmed: 19129539
J Clin Endocrinol Metab. 2009 Mar;94(3):741-5
pubmed: 19088166
N Engl J Med. 2017 Jan 12;376(2):125-135
pubmed: 28076709
Endocr Relat Cancer. 2016 Sep;23(9):759-67
pubmed: 27552969
Nat Commun. 2013;4:2810
pubmed: 24326773
ANZ J Surg. 2016 Sep;86(9):706-10
pubmed: 25345822
Endocr Relat Cancer. 2015 Feb;22(1):1-9
pubmed: 25376618
J Gastrointest Surg. 2017 Aug;21(8):1335-1341
pubmed: 28510792
Gland Surg. 2018 Feb;7(1):20-27
pubmed: 29629316
Eur J Surg Oncol. 1997 Feb;23(1):36-42
pubmed: 9066745
Lancet. 2011 Dec 10;378(9808):2005-2012
pubmed: 22119496
PLoS One. 2018 Oct 23;13(10):e0206099
pubmed: 30352083
N Engl J Med. 1980 Nov 20;303(21):1189-94
pubmed: 6252466
Surgery. 1984 Dec;96(6):1027-37
pubmed: 6095477
Endocr Pract. 2011 Mar-Apr;17(2):e17-20
pubmed: 21247848
Clin Endocrinol (Oxf). 2018 Feb;88(2):341-343
pubmed: 29055143
AJR Am J Roentgenol. 2003 Sep;181(3):775-80
pubmed: 12933480
Br J Cancer. 1999 Dec;81(8):1351-5
pubmed: 10604732
Best Pract Res Clin Gastroenterol. 2005 Oct;19(5):783-98
pubmed: 16253900
Endocrine. 2017 Apr;56(1):158-163
pubmed: 27905047
Neuroendocrinology. 2015;101(4):274-88
pubmed: 25924937
J Clin Oncol. 2007 May 20;25(15):1967-73
pubmed: 17513802
Gastrointest Endosc. 2012 Jan;75(1):200-6
pubmed: 22078104
Abdom Imaging. 2015 Feb;40(2):299-309
pubmed: 25134801
Hormones (Athens). 2016 Oct;15(4):489-499
pubmed: 28222404
Metabolism. 1964 Apr;13:312-8
pubmed: 14143154
World J Gastroenterol. 2013 Feb 14;19(6):829-37
pubmed: 23430217
J Endocrinol Invest. 2013 Oct;36(9):753-8
pubmed: 23608735
Int J Endocrinol. 2018 Oct 23;2018:2059481
pubmed: 30425741
Cancer. 1999 Sep 15;86(6):944-8
pubmed: 10491519
Neuroendocrinology. 2006;84(3):183-8
pubmed: 17312378
Endocrinol Diabetes Metab Case Rep. 2014;2014:140047
pubmed: 25298880
Best Pract Res Clin Gastroenterol. 2012 Dec;26(6):791-802
pubmed: 23582919
Diabetologia. 2005 Nov;48(11):2236-40
pubmed: 16195867
J Endocrinol Invest. 2019 Mar;42(3):249-260
pubmed: 29949120
N Engl J Med. 1992 Feb 20;326(8):519-23
pubmed: 1310159
Expert Rev Endocrinol Metab. 2010 Mar 1;5(2):217-227
pubmed: 20401170
Future Oncol. 2010 Feb;6(2):229-37
pubmed: 20146582