Cytological differentiation between benign and malignant perianal gland proliferative lesions in dogs: a preliminary study.
Journal
The Journal of small animal practice
ISSN: 1748-5827
Titre abrégé: J Small Anim Pract
Pays: England
ID NLM: 0165053
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
17
10
2018
revised:
05
04
2019
accepted:
31
05
2019
pubmed:
2
8
2019
medline:
2
7
2020
entrez:
2
8
2019
Statut:
ppublish
Résumé
To evaluate the diagnostic utility of individual cytological criteria and their best combination to differentiate benign from malignant perianal gland proliferative lesions in dogs. Retrospective study of cytological samples of canine perianal gland proliferative lesions that had subsequent histopathological confirmation. Seventy-seven perianal gland nodules from 56 dogs were included. Histologically, lesions were diagnosed as hyperplasia (n=2), adenoma (n=53), epithelioma (n=6) and carcinoma (n=16). Of the 28 cytological criteria assessed, 13 showed promise for distinguishing benign from malignant lesions. A diagnostic algorithm with an 87% accuracy (sensitivity, 90.9%; specificity, 85.4%) was developed from these data. Cytological evaluation can provide useful information for presurgical differentiation between benign and malignant hepatoid gland proliferative lesions. The proposed algorithm must be validated and tested for reproducibility in further, preferably larger, series of cases.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
616-622Informations de copyright
© 2019 British Small Animal Veterinary Association.
Références
Berrocal, A. , Vos, J. H. , van den Ingh, T. S. G. A. M. , et al. (1989) Canine perianal tumours. Journal of the Veterinary Medical Association 36, 739-749
Evans, S. J. M. , Connolly, S. L. , Schaffer, P. A. , et al. (2018) Basal cell enumeration does not predict malignancy in canine perianal gland tumor cytology. Veterinary Clinical Pathology 47, 634-637
Fisher, D. J. (2014) Cutaneous and subcutaneous lesions. In: Cowell and Tyler's Diagnostic Cytology and Hematology of the Dog and Cat. 4th edn. Eds A. C. Valenciano and R. L. Cowell . Mosby Elsevier, St. Louis, MO, USA. pp 102-103
Goldschmidt, M. H. & Goldschmidt, K. H. (2017) Epithelial and melanocytic tumors of the skin. In: Tumors in Domestic Animals. 5th edn. Ed D. J. Meuten . Wiley Blackwell, Ames, IA, USA. pp 112-115
Goldschmidt, M. H. , Dunstan, R. W. , Stannard, A. A. , et al. (1998) Histological classification of epithelial and melanocytic tumors of the skin of domestic animals. WHO International Histological Classification of Tumors of Domestic Animals, 2nd series, vol. III, Armed Forces Institute of Pathology, Washington, DC, USA
Gross, T. L. , Ihrke, P. J. , Walder, E. J. , et al. (2005) Skin Diseases of the Dog and Cat: Clinical and Histopathologic Diagnosis. 2nd edn. Blackwell Publishing, Ames, IA, USA. pp 625-648
Hayes, H. M. & Wilson, G. P. (1977) Hormone-dependent neoplasm of the canine perianal gland. Cancer Research 37, 2068-2071
Isitor, G. N. & Weinman, D. E. (1979) Origin and early development of canine circumanal glands. American Journal of Veterinary Research 40, 487-492
Klaassen, J. K. (2002) Cytology of subcutaneous glandular tissues. Veterinary Clinics of North America: Small Animal Practice 32, 1237-1266
McCourt, M. R. , Levine, G. M. , Breshears, M. A. , et al. (2018) Metastatic disease in a dog with a well-differentiated perianal gland tumor. Veterinary Clinical Pathology 47, 649-653. https://doi.org/10.1111/vcp.12662
Nielsen, S. W. & Aftosmis, J. (1964) Canine perianal gland tumors. Journal of the American Veterinary Medical Association 144, 127-135
Pisani, G. , Millanta, F. , Lorenzi, D. , et al. (2006) Androgen receptor expression in normal, hyperplastic and neoplastic hepatoid glands in the dog. Research in Veterinary Science 8, 231-236
Shelly, S. M. (2003) Cutaneous lesion. Veterinary Clinics of North America: Small Animal Practice 33, 1-46
Turek, M. M. & Withrow, S. J. (2013) Perianal tumors. In: Small Animal Clinical Oncology. 5th edn. Eds S. J. Withrow , E. G. MacEwen and R. L. Page . Elsevier Saunders, St. Louis, MO, USA. pp 423-431
Vail, D. M. , Withrow, S. J. , Schwarz, P. D. , et al. (1990) Perianal adenocarcinomas in the canine male: a retrospective study of 41 cases. Journal of the American Animal Hospital Association 26, 329-334
Wilson, G. P. & Hayes, H. M. (1979) Castration for treatment of perianal gland neoplasms in the dog. Journal of the American Veterinary Medical Association 174, 1301-1303