Comparison of screening tests without a gold standard-A pragmatic approach with virtual reference testing.
Diagnostic testing
Mathematical modeling
Rare diseases
Test comparison without gold standard
Test evaluation
Journal
Acta tropica
ISSN: 1873-6254
Titre abrégé: Acta Trop
Pays: Netherlands
ID NLM: 0370374
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
17
12
2018
revised:
24
06
2019
accepted:
26
07
2019
pubmed:
2
8
2019
medline:
21
12
2019
entrez:
2
8
2019
Statut:
ppublish
Résumé
Well-defined diagnostic gold standards are rarely available for the diagnosis of rare diseases such as some tropical infections. Algorithms for reliable test evaluation without gold standard are therefore desirable. On the basis of previous work of Gart and Buck (1966); Rogan and Gladen (1978), and Hui and Walter (1980), a modeling approach for the comparison of diagnostic tests without a gold standard - and thus without reliably characterized reference sample material - is established especially for situations not fulfilling the requirement of conditional independence of the diagnostic tests evaluated. In the approach introduced, each test is conducted within two populations with different values of prevalence and the test results are used to define two virtual reference tests. The model is useful for the comparison of tests for rare tropical diseases where no gold standard can be provided.
Identifiants
pubmed: 31369728
pii: S0001-706X(18)31614-0
doi: 10.1016/j.actatropica.2019.105118
pii:
doi:
Types de publication
Comparative Study
Evaluation Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105118Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.