Developing zebrafish experimental animal models relevant to schizophrenia.

Animals Behavior, Animal / physiology Disease Models, Animal Schizophrenia / genetics Translational Research, Biomedical Zebrafish / physiology
Negative symptoms Positive symptoms Rodent models Schizophrenia Translational research Zebrafish

Journal

Neuroscience and biobehavioral reviews
ISSN: 1873-7528
Titre abrégé: Neurosci Biobehav Rev
Pays: United States
ID NLM: 7806090

Informations de publication

Date de publication:
10 2019
Historique:
received: 02 06 2018
revised: 20 07 2019
accepted: 27 07 2019
pubmed: 2 8 2019
medline: 1 7 2020
entrez: 2 8 2019
Statut: ppublish

Résumé

Schizophrenia is a severely debilitating, lifelong psychiatric disorder affecting approximately 1% of global population. The pathobiology of schizophrenia remains poorly understood, necessitating further translational research in this field. Experimental (animal) models are becoming indispensable for studying schizophrenia-related phenotypes and pro/antipsychotic drugs. Mounting evidence suggests the zebrafish (Danio rerio) as a useful tool to model various phenotypes relevant to schizophrenia. In addition to their complex robust behaviors, zebrafish possess high genetic and physiological homology to humans, and are also sensitive to drugs known to reduce or promote schizophrenia clinically. Here, we summarize findings on zebrafish application to modeling schizophrenia, as well as discuss recent progress and remaining challenges in this field. We also emphasize the need in further development and wider use of zebrafish models for schizophrenia to better understand its pathogenesis and enhance the search for new effective antipsychotics.

Identifiants

DOI: 10.1016/j.neubiorev.2019.07.017 PMID: 31369798
pubmed: 31369798
pii: S0149-7634(18)30417-2
doi: 10.1016/j.neubiorev.2019.07.017
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

126-133

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Konstantin A Demin (KA)

Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia.

Darya A Meshalkina (DA)

Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.

Andrey D Volgin (AD)

Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Translational Biopsychiatry Laboratory, Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia.

Oleg V Yakovlev (OV)

Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.

Murilo S de Abreu (MS)

Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil; Postgraduate Program in Pharmacology, Federal University of Santa Maria, Santa Maria, Brazil; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA.

Polina A Alekseeva (PA)

Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia.

Ashton J Friend (AJ)

Tulane University School of Science and Engineering, New Orleans, LA, USA; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA; ZENEREI Research Center, Slidell, LA, USA.

Anton M Lakstygal (AM)

Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Institute of Experimental Medicine, Almazov National Medical Research Centre, St. Petersburg, Russia; Russian Center for Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia.

Konstantin Zabegalov (K)

The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA; Ural Federal University, Ekaterinburg, Russia; Laboratory of Biological Psychiatry, Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.

Tamara G Amstislavskaya (TG)

Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA.

Tatyana Strekalova (T)

Sechenov First Moscow State Medical University, Institute of Molecular Medicine, Laboratory of Psychiatric Neurobiology and Department of Normal Physiology, Moscow, Russia; Neuroscience Program, University of Maastricht, Maastricht, the Netherlands; Institute of General Pathology and Pathophysiology, Moscow, Russia.

Wandong Bao (W)

School of Pharmacy, Southwest University, Chongqing, China; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA.

Allan V Kalueff (AV)

School of Pharmacy, Southwest University, Chongqing, China; Ural Federal University, Ekaterinburg, Russia. Electronic address: avkalueff@gmail.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Developing zebrafish experimental animal...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement animal › Developing zebrafish experimental animal...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Developing zebrafish experimental animal...
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Schizophrénie › Developing zebrafish experimental animal...
questionsmedicales.fr › Disciplines des sciences naturelles › Science › Recherche › Recherche biomédicale › Recherche médicale translationnelle › Developing zebrafish experimental animal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Developing zebrafish experimental animal...