Cognitive functioning in glioma patients is related to functional connectivity measures of the non-tumoural hemisphere.
Adult
Attention
/ physiology
Brain
/ physiopathology
Brain Mapping
/ methods
Brain Neoplasms
/ physiopathology
Cognition
/ physiology
Female
Functional Laterality
/ physiology
Glioma
/ pathology
Humans
Image Processing, Computer-Assisted
/ methods
Magnetic Resonance Imaging
/ methods
Male
Middle Aged
Nerve Net
/ physiopathology
Neural Pathways
/ physiopathology
assortativity
cognitive functioning
contralesional
local efficiency
resting state
Journal
The European journal of neuroscience
ISSN: 1460-9568
Titre abrégé: Eur J Neurosci
Pays: France
ID NLM: 8918110
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
12
11
2018
revised:
04
07
2019
accepted:
22
07
2019
pubmed:
2
8
2019
medline:
24
9
2020
entrez:
2
8
2019
Statut:
ppublish
Résumé
Previous studies have shown that cognitive functioning in patients with brain tumour is associated with the functional network characteristics of specific resting-state networks or with whole-brain network characteristics. These studies, however, did not acknowledge the functional contribution of areas in the contralesional, non-tumoural hemisphere, even though these healthy remote areas likely play a critical role in compensating for the loss of function in damaged tissue. In the current study, we examined whether there is an association between cognitive performance and functional network features of the contralesional hemisphere of patients with glioma. We found that local efficiency of the contralesional hemisphere was associated with performance on the reaction time domain, whereas contralesional assortativity was associated with complex attention and cognitive flexibility scores. Our results suggest that a less segregated organization of the contralesional hemisphere is associated with better reaction time scores, whereas a better spread of information over the contralesional hemisphere through mutually interconnected contralesional hubs is associated with better cognitive flexibility and better complex attention scores. These findings urge researchers to recognize the functional contribution of remote, undamaged regions and to focus more on the graph metrics of the contralesional hemisphere in the search for predictors of cognitive functioning in patients with brain tumour.
Identifiants
pubmed: 31370107
doi: 10.1111/ejn.14535
pmc: PMC6972640
doi:
Banques de données
figshare
['m9.figshare.c.4586678.v1']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3921-3933Informations de copyright
© 2019 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
Références
Assessment. 2020 Mar;27(2):373-383
pubmed: 28895436
J Neurosci. 2016 Nov 30;36(48):12083-12094
pubmed: 27903719
J Neurooncol. 2012 Jun;108(2):231-7
pubmed: 22331519
Neuron. 2010 Nov 4;68(3):401-8
pubmed: 21040843
Stroke. 2005 Aug;36(8):1759-63
pubmed: 16020770
Clin Neurophysiol. 2006 Sep;117(9):2039-49
pubmed: 16859985
Neuro Oncol. 2019 Jul 11;21(7):911-922
pubmed: 30753679
Neuron. 2011 Nov 17;72(4):665-78
pubmed: 22099467
Neuroimage. 2013 Aug 15;77:207-14
pubmed: 23567890
Neuroimage. 2018 May 1;171:323-331
pubmed: 29339311
Neurosci Lett. 2013 May 24;543:27-31
pubmed: 23562503
Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14595-600
pubmed: 12391312
J Neurooncol. 2017 Aug;134(1):9-18
pubmed: 28567586
Nat Neurosci. 2005 Nov;8(11):1603-10
pubmed: 16234807
Oncologist. 2010;15(6):618-26
pubmed: 20507891
Science. 2013 Nov 1;342(6158):1238411
pubmed: 24179229
Science. 2002 May 3;296(5569):910-3
pubmed: 11988575
Brain Connect. 2013;3(2):99-120
pubmed: 23294010
Neuroimage. 2002 Jan;15(1):273-89
pubmed: 11771995
Brain Connect. 2012;2(1):25-32
pubmed: 22432927
Arq Neuropsiquiatr. 2011 Aug;69(4):596-601
pubmed: 21877026
Nat Neurosci. 2016 Jan;19(1):165-71
pubmed: 26595653
Neural Plast. 2016;2016:2365063
pubmed: 27478645
Trends Cogn Sci. 2010 Jun;14(6):277-90
pubmed: 20493761
Trends Cogn Sci. 2004 Sep;8(9):418-25
pubmed: 15350243
PLoS One. 2015 Apr 13;10(4):e0123950
pubmed: 25875001
Neuroimage. 2017 Jul 1;154:128-149
pubmed: 27956209
Nat Rev Neurosci. 2015 Mar;16(3):159-72
pubmed: 25697159
Sci Rep. 2017 Feb 07;7:42117
pubmed: 28169349
Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8577-82
pubmed: 16723398
Brain Connect. 2016 May;6(4):298-311
pubmed: 26860437
Nat Rev Neurosci. 2009 Mar;10(3):186-98
pubmed: 19190637
Neuroimage. 2017 May 15;152:437-449
pubmed: 28167349
Sci Rep. 2017 Jan 05;7:40107
pubmed: 28054664
Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Feb;69(2 Pt 2):026113
pubmed: 14995526
Brain. 2016 Dec;139(Pt 12):3063-3083
pubmed: 27497487
Neuroimage. 2012 Oct 15;63(1):203-11
pubmed: 22766165
Neuroimage. 2017 Oct 15;160:113-123
pubmed: 27919750
Brain. 2015 Jun;138(Pt 6):1696-709
pubmed: 25808370
Phys Rev Lett. 2002 Nov 11;89(20):208701
pubmed: 12443515
PLoS One. 2012;7(11):e50122
pubmed: 23166829
J Neurol Sci. 2003 Dec 15;216(1):1-10
pubmed: 14607296
Brain. 2006 Mar;129(Pt 3):791-808
pubmed: 16364955
Cortex. 2013 Mar;49(3):837-49
pubmed: 22699024
Brain Connect. 2012;2(3):125-41
pubmed: 22642651
Lancet Neurol. 2008 Jun;7(6):548-60
pubmed: 18485318
Neuropsychology. 2019 Jan;33(1):103-110
pubmed: 30475049
Neuroimage. 2010 Sep;52(3):1059-69
pubmed: 19819337
J Clin Oncol. 2009 Aug 1;27(22):3712-22
pubmed: 19470928
PLoS One. 2012;7(7):e40231
pubmed: 22808124
Stroke. 2003 Jun;34(6):1553-66
pubmed: 12738893
Neural Plast. 2017;2017:3530723
pubmed: 28845308
PLoS Comput Biol. 2009 May;5(5):e1000395
pubmed: 19492086
Hum Brain Mapp. 2010 Jul;31(7):1017-29
pubmed: 20091792
J Neurosci. 2009 Jun 10;29(23):7619-24
pubmed: 19515930
Eur J Neurosci. 2019 Dec;50(12):3921-3933
pubmed: 31370107
J Neurooncol. 2014 Jan;116(2):373-9
pubmed: 24234804
Cereb Cortex. 2002 Sep;12(9):908-14
pubmed: 12183390
PLoS Comput Biol. 2007 Feb 2;3(2):e17
pubmed: 17274684
Trends Cogn Sci. 2013 Dec;17(12):666-82
pubmed: 24238796
J Neurooncol. 2017 Feb;131(3):565-574
pubmed: 27848136
Neuro Oncol. 2015 Apr;17(4):580-7
pubmed: 25227126
Nat Rev Neurosci. 2012 Apr 13;13(5):336-49
pubmed: 22498897
Ann Neurol. 2011 Mar;69(3):521-32
pubmed: 21400562
Curr Opin Oncol. 2014 Nov;26(6):627-33
pubmed: 25188475
Arch Clin Neuropsychol. 2006 Oct;21(7):623-43
pubmed: 17014981
J Neurooncol. 2011 Jul;103(3):541-9
pubmed: 20878206
Brain Struct Funct. 2014 Jan;219(1):193-209
pubmed: 23232826
Brain Connect. 2016 Aug 22;6(8):587-595
pubmed: 27457676
PLoS One. 2015 Feb 06;10(2):e0118072
pubmed: 25659130
J Clin Neuropsychol. 1984 Aug;6(3):309-24
pubmed: 6470167
Expert Rev Anticancer Ther. 2012 Feb;12(2):255-69
pubmed: 22316373
J Neurophysiol. 2003 Jun;89(6):3205-14
pubmed: 12783955
Nature. 2016 Aug 11;536(7615):171-178
pubmed: 27437579
Neuroscience. 2011 Feb 23;175:169-77
pubmed: 21130847
Neuroimage. 2010 Sep;52(3):766-76
pubmed: 20116438
Ann Neurol. 2005 Jan;57(1):128-31
pubmed: 15622534
Phys Rev Lett. 2001 Nov 5;87(19):198701
pubmed: 11690461