Decreased Sensitivity of the Serological Detection of Feline Immunodeficiency Virus Infection Potentially Due to Imported Genetic Variants.
Animals
Cats
Communicable Diseases, Imported
/ blood
Enzyme-Linked Immunosorbent Assay
/ standards
False Negative Reactions
Female
Genetic Variation
Immunodeficiency Virus, Feline
/ genetics
Lentivirus Infections
/ blood
Male
Pets
/ virology
Point-of-Care Testing
/ standards
Sensitivity and Specificity
Switzerland
Feline immunodeficiency virus
Western blot
domestic cat
gold standard
lentivirus
point-of-care test
retrovirus
serology
veterinary sciences
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
31 07 2019
31 07 2019
Historique:
received:
04
07
2019
revised:
26
07
2019
accepted:
29
07
2019
entrez:
3
8
2019
pubmed:
3
8
2019
medline:
26
9
2020
Statut:
epublish
Résumé
Feline immunodeficiency virus (FIV) is a lentivirus of domestic cats worldwide. Diagnosis usually relies on antibody screening by point-of-care tests (POCT), e.g., by enzyme-linked immunosorbent assays (ELISA), and confirmation using Western blot (WB). We increasingly observed ELISA-negative, WB-positive samples and aimed to substantiate these observations using 1194 serum/plasma samples collected from 1998 to 2019 primarily from FIV-suspect cats. While 441 samples tested positive and 375 tested negative by ELISA and WB, 81 samples had discordant results: 70 were false ELISA-negative (WB-positive) and 11 were false ELISA-positive (WB-negative); 297 ambiguous results were not analyzed further. The diagnostic sensitivity and specificity of the ELISA (82% and 91%, respectively) were lower than those reported in 1995 (98% and 97%, respectively). The diagnostic efficiency was reduced from 97% to 86%. False ELISA-negative samples originated mainly (54%) from Switzerland (1995: 0%). Sixty-four false ELISA-negative samples were available for POCT (SNAP
Identifiants
pubmed: 31370217
pii: v11080697
doi: 10.3390/v11080697
pmc: PMC6722909
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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