Synthesis and In Vitro Evaluation of 8-Pyridinyl-Substituted Benzo[
Benzoimidazotriazine (BIT)
Mouse Liver Microsomes (MLM)
Phosphodiesterase 2A (PDE2A)
Positron Emission Tomography (PET)
fluorinated
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
31 Jul 2019
31 Jul 2019
Historique:
received:
24
05
2019
revised:
17
07
2019
accepted:
26
07
2019
entrez:
3
8
2019
pubmed:
3
8
2019
medline:
4
1
2020
Statut:
epublish
Résumé
Phosphodiesterase 2A (PDE2A) is highly expressed in distinct areas of the brain, which are known to be related to neuropsychiatric diseases. The development of suitable PDE2A tracers for Positron Emission Tomography (PET) would permit the
Identifiants
pubmed: 31370274
pii: molecules24152791
doi: 10.3390/molecules24152791
pmc: PMC6696243
pii:
doi:
Substances chimiques
Ligands
0
Radiopharmaceuticals
0
Triazines
0
Cyclic Nucleotide Phosphodiesterases, Type 2
EC 3.1.4.17
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : SCHE 1825/3-1
Organisme : Indonesia Ministry of Research and Technology-Program for Research and Innovation in Science and Technology Project (RISET-Pro)
ID : World Bank Loan No: 8245-ID
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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