Reliability of Instantaneous Wave-Free Ratio (iFR) for the Evaluation of Left Main Coronary Artery Lesions.
coronary stenosis
fractional flow reserve (FFR)
instantaneous wave-free ratio (iFR)
left main coronary artery (LMCA)
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
31 07 2019
31 07 2019
Historique:
received:
18
06
2019
revised:
20
07
2019
accepted:
30
07
2019
entrez:
3
8
2019
pubmed:
3
8
2019
medline:
3
8
2019
Statut:
epublish
Résumé
The assessment of the left main coronary artery (LMCA) by coronary angiography has several limitations. The fractional flow reserve (FFR) is useful for the functional evaluation of LMCA stenoses. The instantaneous wave-free ratio (iFR), a resting index, was developed to simplify functional coronary assessment. However, its performance for LMCA stenoses has yet to be explored. The iFR was measured at rest, and the FFR was measured under maximal hyperemia. We calculated that a sample size of 90 lesions would have provided 90% power at a 5% significance level to detect an Area Under the Curve (AUC) < 0.7 for the iFR to identify FFR-positive stenoses. A total of 91 measurements were performed on angiographically intermediate LMCA stenoses at three centers. The comparison between the iFR and the FFR showed a significant correlation (r = 0.67,
Identifiants
pubmed: 31370353
pii: jcm8081143
doi: 10.3390/jcm8081143
pmc: PMC6724021
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : PON03PE_00009_4
Pays : International
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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