Genetic predictors of chemotherapy-related amenorrhea in women with breast cancer.
Breast neoplasms
amenorrhea
drug therapy
toxicity
Journal
Fertility and sterility
ISSN: 1556-5653
Titre abrégé: Fertil Steril
Pays: United States
ID NLM: 0372772
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
16
01
2019
revised:
10
05
2019
accepted:
16
05
2019
pubmed:
3
8
2019
medline:
29
5
2020
entrez:
3
8
2019
Statut:
ppublish
Résumé
To study how genetics may play a role in determining risk of chemotherapy-related amenorrhea (CRA) in young women with breast cancer. Genome-wide association study. Not applicable. Premenopausal women ≤45 years of age enrolled in one of these three trials were included if they had at least one menstrual case report form after chemotherapy ended and if they were of European ancestry. Forms during and up to 3 months after receipt of GnRH agonist were excluded. None. The association of single-nucleotide polymorphisms with post-chemotherapy menstruation adjusted for trial and arm, age, tamoxifen use, and nodal status. The median age of the 1,168 women was 41 years (range 19-45). Among these, 457 (39%) never resumed menses after chemotherapy. Older age, tamoxifen use, and node-negative disease were associated with increased risk of CRA. Adjusting for these, rs147451859, in an intron of PPCDC (phosphopantothenoylcysteine decarboxylase), and rs17587029, located 5' upstream of RPS20P11 (ribosomal protein S20 pseudogene 11), were associated with post-chemotherapy menstruation. Genetic variation may contribute to risk of CRA. Better prediction of who will experience CRA may inform reproductive and treatment decision making in young women with cancer.
Identifiants
pubmed: 31371054
pii: S0015-0282(19)30475-3
doi: 10.1016/j.fertnstert.2019.05.018
pmc: PMC6765404
mid: NIHMS1529950
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
731-739.e1Subventions
Organisme : NCATS NIH HHS
ID : KL2 TR002379
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG004438
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG005157
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR000136
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG005137
Pays : United States
Informations de copyright
Copyright © 2019 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Références
Genetics. 2000 Jun;155(2):945-59
pubmed: 10835412
J Biol Chem. 2002 Jun 14;277(24):21431-9
pubmed: 11923312
J Clin Endocrinol Metab. 2005 Jun;90(6):3427-30
pubmed: 15769979
Nat Genet. 2007 Oct;39(10):1181-6
pubmed: 17898773
Breast Cancer Res Treat. 2009 Jan;113(2):315-20
pubmed: 18302020
Genet Epidemiol. 2008 May;32(4):381-5
pubmed: 18348202
Nature. 2008 May 22;453(7194):539-43
pubmed: 18404146
Nature. 2008 May 22;453(7194):534-8
pubmed: 18404147
Acta Oncol. 2008;47(4):545-9
pubmed: 18465320
Genome Biol. 2009;10(1):R2
pubmed: 19123937
Cancer. 2010 Feb 15;116(4):791-8
pubmed: 20052714
Bioinformatics. 2010 Sep 15;26(18):2336-7
pubmed: 20634204
N Engl J Med. 2010 Jul 8;363(2):166-76
pubmed: 20647212
Bioinformatics. 2010 Nov 15;26(22):2867-73
pubmed: 20926424
Breast Care (Basel). 2010;5(6):395-400
pubmed: 21494405
Breast. 2012 Jun;21(3):272-5
pubmed: 22018510
Nucleic Acids Res. 2012 Jan;40(Database issue):D930-4
pubmed: 22064851
Fertil Steril. 2012 Jan;97(1):154-9
pubmed: 22192139
PLoS Genet. 2012;8(6):e1002707
pubmed: 22685416
Genome Res. 2012 Sep;22(9):1790-7
pubmed: 22955989
J Clin Oncol. 2013 Jan 1;31(1):73-9
pubmed: 23169515
Nat Genet. 2013 Jun;45(6):580-5
pubmed: 23715323
Nat Genet. 2013 Oct;45(10):1238-1243
pubmed: 24013639
Psychooncology. 2014 Feb;23(2):173-82
pubmed: 24038775
J Clin Oncol. 2014 Apr 10;32(11):1151-6
pubmed: 24567428
Geburtshilfe Frauenheilkd. 2013 Jan;73(1):63-69
pubmed: 24771886
Cancer. 2014 Aug 1;120(15):2264-71
pubmed: 24891236
Int J Epidemiol. 2015 Feb;44(1):324-33
pubmed: 25501468
Nature. 2015 Feb 19;518(7539):317-30
pubmed: 25693563
Breast Cancer Res. 2015 Sep 18;17:129
pubmed: 26385214
Nat Genet. 2015 Nov;47(11):1294-1303
pubmed: 26414677
Geburtshilfe Frauenheilkd. 2015 Dec;75(12):1243-1249
pubmed: 26726265
BMC Cancer. 2016 May 27;16:337
pubmed: 27234217
Nat Genet. 2016 Oct;48(10):1284-1287
pubmed: 27571263
Mayo Clin Proc. 2016 Nov;91(11):1577-1589
pubmed: 27693001
Clin Breast Cancer. 2017 Jun;17(3):e135-e142
pubmed: 27986439
Genome Biol. 2017 Jan 25;18(1):16
pubmed: 28122634
Arch Gynecol Obstet. 2017 Apr;295(4):1033-1039
pubmed: 28197717
Breast. 2017 Oct;35:203-217
pubmed: 28822332
Geburtshilfe Frauenheilkd. 2017 Aug;77(8):861-869
pubmed: 28845050
Nat Genet. 2017 Dec;49(12):1767-1778
pubmed: 29058716
BMC Med Res Methodol. 2018 Jan 04;18(1):2
pubmed: 29301487
Cancer. 2019 Jan 15;125(2):307-316
pubmed: 30335191