Methotrexate-associated toxicity in children with Down syndrome and acute lymphoblastic leukemia during consolidation therapy with high dose methotrexate according to ALL-BFM treatment regimen.
Journal
Haematologica
ISSN: 1592-8721
Titre abrégé: Haematologica
Pays: Italy
ID NLM: 0417435
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
15
04
2019
accepted:
24
07
2019
pubmed:
3
8
2019
medline:
28
4
2021
entrez:
3
8
2019
Statut:
ppublish
Résumé
Children with Down syndrome (DS) and acute lymphoblastic leukemia (ALL) often suffer from severe toxicities during treatment, especially with high-dose methotrexate (HD-MTX). Systematic data on methotrexate (MTX) toxicity in these patients are rare. We analyzed seven MTX-associated toxicities during consolidation therapy in 103 DS- and 1,109 non-DS-patients (NDS) with ALL (NDS-ALL) enrolled in ALL-Berlin-Frankfurt-Münster (ALL-BFM) trials between 1995-2016 and 1995-2007, respectively. Patients received four courses MTX (5 g/m
Identifiants
pubmed: 31371414
pii: haematol.2019.224774
doi: 10.3324/haematol.2019.224774
pmc: PMC7109740
doi:
Substances chimiques
Mercaptopurine
E7WED276I5
Methotrexate
YL5FZ2Y5U1
Banques de données
ClinicalTrials.gov
['NCT01117441']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1013-1020Informations de copyright
Copyright© 2020 Ferrata Storti Foundation.
Références
Blood. 2014 Jan 2;123(1):70-7
pubmed: 24222333
Rheumatology (Oxford). 2008 Apr;47(4):451-3
pubmed: 18316334
Br J Haematol. 2009 Sep;146(5):489-503
pubmed: 19538530
Blood. 2013 Jun 27;121(26):5145-53
pubmed: 23652803
Eur J Clin Pharmacol. 1981;19(6):453-6
pubmed: 7250179
Br J Haematol. 2006 Dec;135(5):595-602
pubmed: 17054672
Int J Hematol. 2011 Feb;93(2):192-198
pubmed: 21286878
Anticancer Drugs. 2009 Jan;20(1):7-14
pubmed: 19342996
Am J Clin Nutr. 2004 Dec;80(6):1667-9
pubmed: 15585786
Blood. 2014 Aug 14;124(7):1056-61
pubmed: 24904116
Haematologica. 2010 Jul;95(7):1106-13
pubmed: 20418240
Blood Res. 2016 Mar;51(1):50-7
pubmed: 27104192
Cancer. 2008 Aug 1;113(3):515-21
pubmed: 18521927
Leukemia. 1998 May;12(5):645-51
pubmed: 9593260
Clin Cancer Res. 2001 Nov;7(11):3416-22
pubmed: 11705857
Drug Metab Dispos. 2014 Apr;42(4):632-49
pubmed: 24396145
Pediatr Blood Cancer. 2018 Feb;65(2):
pubmed: 28921818
Genet Med. 2016 Nov;18(11):1151-1157
pubmed: 27031084
Pediatr Blood Cancer. 2009 Jan;52(1):14-9
pubmed: 18802938
N Engl J Med. 2015 Dec 31;373(27):2691-3
pubmed: 26716929
Blood. 2005 Dec 15;106(13):4043-9
pubmed: 16109782
F1000Res. 2017 Apr 7;6:444
pubmed: 28413626
Br J Haematol. 2016 Sep;174(6):983-5
pubmed: 26457881
Pediatr Blood Cancer. 2005 Jan;44(1):33-9
pubmed: 15390307