Serotonin receptor oligomerization regulates cAMP-based signaling.

Animals Cell Line, Tumor Cyclic AMP / genetics Mice Protein Multimerization Receptor, Serotonin, 5-HT1A / genetics Receptors, Serotonin / genetics Second Messenger Systems
5-HT1AR 5-HT7R Epac FRET Förster resonance energy transfer G protein-coupled receptor GPCR Hetero-oligomerization Lux-FRET Quantitative confocal microscopy Stoichiometry cAMP signaling

Journal

Journal of cell science
ISSN: 1477-9137
Titre abrégé: J Cell Sci
Pays: England
ID NLM: 0052457

Informations de publication

Date de publication:
23 08 2019
Historique:
received: 25 01 2019
accepted: 22 07 2019
pubmed: 3 8 2019
medline: 9 7 2020
entrez: 3 8 2019
Statut: epublish

Résumé

Protein-protein interaction is often investigated using quantitative molecular microscopy with Förster resonant energy transfer (FRET). Here, we combined 'linear unmixing FRET' (lux-FRET) with the simultaneous application of a FRET-based biosensor for cAMP to investigate the oligomerization between the 5-HT

Identifiants

DOI: 10.1242/jcs.230334 PMID: 31371490
pubmed: 31371490
pii: jcs.230334
doi: 10.1242/jcs.230334
pii:
doi:

Substances chimiques

Htr1a protein, mouse 0
Receptors, Serotonin 0
serotonin 7 receptor 0
Receptor, Serotonin, 5-HT1A 112692-38-3
Cyclic AMP E0399OZS9N

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2019. Published by The Company of Biologists Ltd.

Déclaration de conflit d'intérêts

Competing interestsThe authors declare no competing or financial interests.

Auteurs

Sonal Prasad (S)

Cellular Neurophysiology, Center of Physiology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.
ORCID: 0000-0002-4455-5097

Evgeni Ponimaskin (E)

Cellular Neurophysiology, Center of Physiology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.
Department of Behavioral Neurogenomics, Institute of Cytology and Genetics, Lavrentyeva av., 10 630090, Novosibirsk, Russia.
ORCID: 0000-0002-4570-5130

Andre Zeug (A)

Cellular Neurophysiology, Center of Physiology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany Zeug.Andre@mh-hannover.de.
ORCID: 0000-0001-9858-5841

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Serotonin receptor oligomerization regulates...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Serotonin receptor oligomerization regulates...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › AMP cyclique › Serotonin receptor oligomerization regulates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Serotonin receptor oligomerization regulates...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Multimérisation de protéines › Serotonin receptor oligomerization regulates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs sérotoninergiques › Récepteurs de la sérotonine de type 5-HT1 › Récepteur de la sérotonine de type 5-HT1A › Serotonin receptor oligomerization regulates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs sérotoninergiques › Serotonin receptor oligomerization regulates...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Systèmes de seconds messagers › Serotonin receptor oligomerization regulates...