X-ray induced photodynamic therapy with copper-cysteamine nanoparticles in mice tumors.
cancer
copper-cysteamine
nanoparticles
photosensitization
radiotherapy
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
20 08 2019
20 08 2019
Historique:
pubmed:
3
8
2019
medline:
26
3
2020
entrez:
3
8
2019
Statut:
ppublish
Résumé
Photodynamic therapy (PDT), a treatment that uses a photosensitizer, molecular oxygen, and light to kill target cells, is a promising cancer treatment method. However, a limitation of PDT is its dependence on light that is not highly penetrating, precluding the treatment of tumors located deep in the body. Copper-cysteamine nanoparticles are a new type of photosensitizer that can generate cytotoxic singlet oxygen molecules upon activation by X-rays. In this paper, we report on the use of copper-cysteamine nanoparticles, designed to be targeted to tumors, for X-ray-induced PDT. In an in vivo study, results show a statistically significant reduction in tumor size under X-ray activation of pH-low insertion peptide-conjugated, copper-cysteamine nanoparticles in mouse tumors. This work confirms the effectiveness of copper-cysteamine nanoparticles as a photosensitizer when activated by radiation and suggests that these Cu-Cy nanoparticles may be good candidates for PDT in deeply seated tumors when combined with X-rays and conjugated to a tumor-targeting molecule.
Identifiants
pubmed: 31371494
pii: 1900502116
doi: 10.1073/pnas.1900502116
pmc: PMC6708320
doi:
Substances chimiques
Peptides
0
Cysteamine
5UX2SD1KE2
Copper
789U1901C5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
16823-16828Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103430
Pays : United States
Organisme : NCI NIH HHS
ID : R15 CA199020
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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