Retinal and optic nerve degeneration in liver X receptor β knockout mice.
Amyloid beta-Peptides
/ metabolism
Animals
Aquaporin 4
/ metabolism
Astrocytes
/ metabolism
Female
Liver X Receptors
/ deficiency
Mice, Inbred C57BL
Mice, Knockout
Nerve Degeneration
/ metabolism
Neuroglia
/ metabolism
Oligodendroglia
/ metabolism
Optic Nerve
/ metabolism
Retina
/ metabolism
Retinal Ganglion Cells
/ metabolism
aquaporin 4
nuclear receptor
optic neuritis
retinal degeneration
β amyloid
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
13 08 2019
13 08 2019
Historique:
pubmed:
3
8
2019
medline:
26
3
2020
entrez:
3
8
2019
Statut:
ppublish
Résumé
The retina is an extension of the brain. Like the brain, neurodegeneration of the retina occurs with age and is the cause of several retinal diseases including optic neuritis, macular degeneration, and glaucoma. Liver X receptors (LXRs) are expressed in the brain where they play a key role in maintenance of cerebrospinal fluid and the health of dopaminergic neurons. Herein, we report that LXRs are expressed in the retina and optic nerve and that loss of LXRβ, but not LXRα, leads to loss of ganglion cells in the retina. In the retina of LXRβ
Identifiants
pubmed: 31371497
pii: 1904719116
doi: 10.1073/pnas.1904719116
pmc: PMC6697819
doi:
Substances chimiques
Amyloid beta-Peptides
0
Aquaporin 4
0
Liver X Receptors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
16507-16512Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
J Clin Invest. 2001 Mar;107(5):565-73
pubmed: 11238557
Invest Ophthalmol Vis Sci. 2002 Feb;43(2):573-9
pubmed: 11818406
Invest Ophthalmol Vis Sci. 2002 Apr;43(4):1077-87
pubmed: 11923249
Lancet. 2004 Dec 11-17;364(9451):2106-12
pubmed: 15589308
Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3857-62
pubmed: 15738425
J Exp Med. 2005 Aug 15;202(4):473-7
pubmed: 16087714
J Neurochem. 1991 Jan;56(1):266-72
pubmed: 1670954
J Neuroimmunol. 2007 Feb;183(1-2):50-9
pubmed: 17175031
Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10601-6
pubmed: 17563384
Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13444-9
pubmed: 17684098
Neurochem Int. 2009 Mar-Apr;54(3-4):143-60
pubmed: 19114072
Cell. 2010 Mar 19;140(6):918-34
pubmed: 20303880
Age (Dordr). 2012 Jun;34(3):633-49
pubmed: 21559868
Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3030-4
pubmed: 22323586
PLoS One. 2012;7(5):e37926
pubmed: 22629470
Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13112-7
pubmed: 22826221
Diabetes. 2012 Dec;61(12):3270-9
pubmed: 22891211
Prog Retin Eye Res. 2013 Sep;36:159-71
pubmed: 23545439
Toxicol Appl Pharmacol. 2013 Dec 1;273(2):242-58
pubmed: 23680456
Lancet Neurol. 2014 Jan;13(1):83-99
pubmed: 24331795
Invest Ophthalmol Vis Sci. 2014 Apr 28;55(4):2795-804
pubmed: 24699378
Cell Mol Life Sci. 2014 Dec;71(23):4617-36
pubmed: 25156067
Invest Ophthalmol Vis Sci. 2015 Jan 22;56(2):1168-80
pubmed: 25613943
Mol Psychiatry. 2016 Jun;21(6):844-56
pubmed: 26324101
Okajimas Folia Anat Jpn. 2015;92(1):11-30
pubmed: 26448374
Ann Neurol. 2016 Jan;79(1):90-109
pubmed: 26505992
Mol Aspects Med. 2016 Jun;49:31-46
pubmed: 27091047
Trends Endocrinol Metab. 2016 Jun;27(6):404-414
pubmed: 27113081
Front Neurol. 2016 Aug 08;7:127
pubmed: 27551275
Prog Lipid Res. 2016 Oct;64:152-169
pubmed: 27687912
J Biol Chem. 2017 Sep 1;292(35):14636-14648
pubmed: 28710278
Front Aging Neurosci. 2017 Jul 06;9:214
pubmed: 28729832
Neuroscience. 2017 Sep 30;360:48-60
pubmed: 28760679
EBioMedicine. 2017 Aug;22:181-190
pubmed: 28774737
Hum Mol Genet. 2017 Oct 1;26(R2):R139-R150
pubmed: 28977448
Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):E2725-E2733
pubmed: 29507213
J Alzheimers Dis. 2018;64(4):1261-1273
pubmed: 30040712
Am J Pathol. 2019 Feb;189(2):405-425
pubmed: 30448403
Elife. 2018 Dec 18;7:
pubmed: 30561329
Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):2096-100
pubmed: 7892230
Mol Cell Biol. 1994 Oct;14(10):7025-35
pubmed: 7935418
J Neurosci. 1997 Jan 1;17(1):171-80
pubmed: 8987746
J Neurosci. 1998 Apr 1;18(7):2506-19
pubmed: 9502811