New and expanding ventricular hemorrhage predicts poor outcome in acute intracerebral hemorrhage.

Aged Aged, 80 and over Cerebral Hemorrhage / diagnosis Cerebral Ventricles / blood supply Cohort Studies Female Humans Linear Models Male Middle Aged Nonlinear Dynamics Outcome Assessment, Health Care / statistics & numerical data Tomography, X-Ray Computed

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
27 08 2019
Historique:
received: 18 12 2018
accepted: 04 04 2019
pubmed: 3 8 2019
medline: 6 2 2020
entrez: 3 8 2019
Statut: ppublish

Résumé

To describe the relationship between intraventricular hemorrhage (IVH) expansion and long-term outcome and to use this relationship to select and validate clinically relevant thresholds of IVH expansion in 2 separate intracerebral hemorrhage (ICH) populations. We used fractional polynomial analysis to test linear and nonlinear models of 24-hour IVH volume change and clinical outcome with data from the Predicting Hematoma Growth and Outcome in Intracerebral Hemorrhage Using Contrast Bolus CT (PREDICT)-ICH study. The primary outcome was poor clinical outcome (modified Rankin Scale [mRS] score 4-6) at 90 days. We derived dichotomous thresholds from the selected model and calculated diagnostic accuracy measures. We validated all thresholds in an independent single-center ICH cohort (Massachusetts General Hospital). Of the 256 patients from PREDICT, 127 (49.6%) had an mRS score of 4 to 6. Twenty-four-hour IVH volume change and poor outcome fit a nonlinear relationship, in which minimal increases in IVH were associated with a high probability of an mRS score of 4 to 6. IVH expansion ≥1 mL (n = 53, sensitivity 33%, specificity 92%, adjusted odds ratio [aOR] 2.68, 95% confidence interval [CI] 1.11-6.46) and development of any new IVH (n = 74, sensitivity 43%, specificity 85%, aOR 2.53, 95% CI 1.22-5.26) strongly predicted poor outcome at 90 days. The dichotomous thresholds reproduced well in a validation cohort of 169 patients. IVH expansion as small as 1 mL or any new IVH is strongly predictive of poor outcome. These findings may assist clinicians with bedside prognostication and could be incorporated into definitions of hematoma expansion to inform future ICH treatment trials.

Identifiants

DOI: 10.1212/WNL.0000000000008007 PMID: 31371565 PMC: PMC6745728
pubmed: 31371565
pii: WNL.0000000000008007
doi: 10.1212/WNL.0000000000008007
pmc: PMC6745728
doi:

Types de publication

Journal Article Multicenter Study Observational Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e879-e888

Subventions

Organisme : NINDS NIH HHS
ID : K23 NS086873
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS103924
Pays : United States

Informations de copyright

© 2019 American Academy of Neurology.

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Auteurs

Vignan Yogendrakumar (V)

From the Ottawa Stroke Program (V.Y., D.D.), Department of Medicine (Neurology), Department of Radiology (C.L.), Ottawa Methods Center (T.R., D.F.), and Ottawa Hospital Research Institute (T.R., D.F., D.D.), University of Ottawa, Ontario; Calgary Stroke Program (A.M.D., M.D.H.), Department of Clinical Neurosciences, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta; Division of Neuroradiology and Department of Medical Imaging (R.I.A.), Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; Department of Neurology (D.R.-L., C.A.M.), Hospital Universitari Vall d'Hebron, Barcelona; Department of Neurology (Y.S.), Dr. Josep Trueta University Hospital, Institut d'Investigació Biomèdica Girona Foundation, Spain; Department of Neurology (I.D.), Elblandklinikum Meissen Academic Teaching Hospital of Technische University, Dresden, Germany; Interventional Stroke and Cerebrovascular Treatment Center and 2nd Department of Neurology (A.K.), Institute of Psychiatry and Neurology, and Department of Experimental and Clinical Pharmacology, Warsaw, Poland; Department of Medicine (J.-M.B.), Charles LeMoyne Hospital, University of Sherbrooke, Longueuil, Quebec; Department of Neurology (G.G.), Dalhousie University, Halifax, Nova Scotia, Canada; Department of Neurology (P.S., R.B.), All India Institute of Medical Sciences, New Delhi; Apollo Gleneagles Hospitals (J.R.), Kolkata, India; Department of Neurology (C.S.K.), Boston Medical Center; and Department of Neurology (A.D.W., C.D.A., M.E.G., S.M.G., A.V., J.R.), Henry and Allison McCance Center for Brain Health (J.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston. vyogendrakumar@toh.on.ca.
ORCID: 0000-0001-8814-6853

Tim Ramsay (T)

From the Ottawa Stroke Program (V.Y., D.D.), Department of Medicine (Neurology), Department of Radiology (C.L.), Ottawa Methods Center (T.R., D.F.), and Ottawa Hospital Research Institute (T.R., D.F., D.D.), University of Ottawa, Ontario; Calgary Stroke Program (A.M.D., M.D.H.), Department of Clinical Neurosciences, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta; Division of Neuroradiology and Department of Medical Imaging (R.I.A.), Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; Department of Neurology (D.R.-L., C.A.M.), Hospital Universitari Vall d'Hebron, Barcelona; Department of Neurology (Y.S.), Dr. Josep Trueta University Hospital, Institut d'Investigació Biomèdica Girona Foundation, Spain; Department of Neurology (I.D.), Elblandklinikum Meissen Academic Teaching Hospital of Technische University, Dresden, Germany; Interventional Stroke and Cerebrovascular Treatment Center and 2nd Department of Neurology (A.K.), Institute of Psychiatry and Neurology, and Department of Experimental and Clinical Pharmacology, Warsaw, Poland; Department of Medicine (J.-M.B.), Charles LeMoyne Hospital, University of Sherbrooke, Longueuil, Quebec; Department of Neurology (G.G.), Dalhousie University, Halifax, Nova Scotia, Canada; Department of Neurology (P.S., R.B.), All India Institute of Medical Sciences, New Delhi; Apollo Gleneagles Hospitals (J.R.), Kolkata, India; Department of Neurology (C.S.K.), Boston Medical Center; and Department of Neurology (A.D.W., C.D.A., M.E.G., S.M.G., A.V., J.R.), Henry and Allison McCance Center for Brain Health (J.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston.
ORCID: 0000-0002-3389-2485

Dean Fergusson (D)

From the Ottawa Stroke Program (V.Y., D.D.), Department of Medicine (Neurology), Department of Radiology (C.L.), Ottawa Methods Center (T.R., D.F.), and Ottawa Hospital Research Institute (T.R., D.F., D.D.), University of Ottawa, Ontario; Calgary Stroke Program (A.M.D., M.D.H.), Department of Clinical Neurosciences, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta; Division of Neuroradiology and Department of Medical Imaging (R.I.A.), Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; Department of Neurology (D.R.-L., C.A.M.), Hospital Universitari Vall d'Hebron, Barcelona; Department of Neurology (Y.S.), Dr. Josep Trueta University Hospital, Institut d'Investigació Biomèdica Girona Foundation, Spain; Department of Neurology (I.D.), Elblandklinikum Meissen Academic Teaching Hospital of Technische University, Dresden, Germany; Interventional Stroke and Cerebrovascular Treatment Center and 2nd Department of Neurology (A.K.), Institute of Psychiatry and Neurology, and Department of Experimental and Clinical Pharmacology, Warsaw, Poland; Department of Medicine (J.-M.B.), Charles LeMoyne Hospital, University of Sherbrooke, Longueuil, Quebec; Department of Neurology (G.G.), Dalhousie University, Halifax, Nova Scotia, Canada; Department of Neurology (P.S., R.B.), All India Institute of Medical Sciences, New Delhi; Apollo Gleneagles Hospitals (J.R.), Kolkata, India; Department of Neurology (C.S.K.), Boston Medical Center; and Department of Neurology (A.D.W., C.D.A., M.E.G., S.M.G., A.V., J.R.), Henry and Allison McCance Center for Brain Health (J.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston.

Andrew M Demchuk (AM)

From the Ottawa Stroke Program (V.Y., D.D.), Department of Medicine (Neurology), Department of Radiology (C.L.), Ottawa Methods Center (T.R., D.F.), and Ottawa Hospital Research Institute (T.R., D.F., D.D.), University of Ottawa, Ontario; Calgary Stroke Program (A.M.D., M.D.H.), Department of Clinical Neurosciences, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta; Division of Neuroradiology and Department of Medical Imaging (R.I.A.), Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; Department of Neurology (D.R.-L., C.A.M.), Hospital Universitari Vall d'Hebron, Barcelona; Department of Neurology (Y.S.), Dr. Josep Trueta University Hospital, Institut d'Investigació Biomèdica Girona Foundation, Spain; Department of Neurology (I.D.), Elblandklinikum Meissen Academic Teaching Hospital of Technische University, Dresden, Germany; Interventional Stroke and Cerebrovascular Treatment Center and 2nd Department of Neurology (A.K.), Institute of Psychiatry and Neurology, and Department of Experimental and Clinical Pharmacology, Warsaw, Poland; Department of Medicine (J.-M.B.), Charles LeMoyne Hospital, University of Sherbrooke, Longueuil, Quebec; Department of Neurology (G.G.), Dalhousie University, Halifax, Nova Scotia, Canada; Department of Neurology (P.S., R.B.), All India Institute of Medical Sciences, New Delhi; Apollo Gleneagles Hospitals (J.R.), Kolkata, India; Department of Neurology (C.S.K.), Boston Medical Center; and Department of Neurology (A.D.W., C.D.A., M.E.G., S.M.G., A.V., J.R.), Henry and Allison McCance Center for Brain Health (J.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston.

Richard I Aviv (RI)

From the Ottawa Stroke Program (V.Y., D.D.), Department of Medicine (Neurology), Department of Radiology (C.L.), Ottawa Methods Center (T.R., D.F.), and Ottawa Hospital Research Institute (T.R., D.F., D.D.), University of Ottawa, Ontario; Calgary Stroke Program (A.M.D., M.D.H.), Department of Clinical Neurosciences, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta; Division of Neuroradiology and Department of Medical Imaging (R.I.A.), Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; Department of Neurology (D.R.-L., C.A.M.), Hospital Universitari Vall d'Hebron, Barcelona; Department of Neurology (Y.S.), Dr. Josep Trueta University Hospital, Institut d'Investigació Biomèdica Girona Foundation, Spain; Department of Neurology (I.D.), Elblandklinikum Meissen Academic Teaching Hospital of Technische University, Dresden, Germany; Interventional Stroke and Cerebrovascular Treatment Center and 2nd Department of Neurology (A.K.), Institute of Psychiatry and Neurology, and Department of Experimental and Clinical Pharmacology, Warsaw, Poland; Department of Medicine (J.-M.B.), Charles LeMoyne Hospital, University of Sherbrooke, Longueuil, Quebec; Department of Neurology (G.G.), Dalhousie University, Halifax, Nova Scotia, Canada; Department of Neurology (P.S., R.B.), All India Institute of Medical Sciences, New Delhi; Apollo Gleneagles Hospitals (J.R.), Kolkata, India; Department of Neurology (C.S.K.), Boston Medical Center; and Department of Neurology (A.D.W., C.D.A., M.E.G., S.M.G., A.V., J.R.), Henry and Allison McCance Center for Brain Health (J.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston.
ORCID: 0000-0003-0259-970X

David Rodriguez-Luna (D)

From the Ottawa Stroke Program (V.Y., D.D.), Department of Medicine (Neurology), Department of Radiology (C.L.), Ottawa Methods Center (T.R., D.F.), and Ottawa Hospital Research Institute (T.R., D.F., D.D.), University of Ottawa, Ontario; Calgary Stroke Program (A.M.D., M.D.H.), Department of Clinical Neurosciences, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta; Division of Neuroradiology and Department of Medical Imaging (R.I.A.), Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; Department of Neurology (D.R.-L., C.A.M.), Hospital Universitari Vall d'Hebron, Barcelona; Department of Neurology (Y.S.), Dr. Josep Trueta University Hospital, Institut d'Investigació Biomèdica Girona Foundation, Spain; Department of Neurology (I.D.), Elblandklinikum Meissen Academic Teaching Hospital of Technische University, Dresden, Germany; Interventional Stroke and Cerebrovascular Treatment Center and 2nd Department of Neurology (A.K.), Institute of Psychiatry and Neurology, and Department of Experimental and Clinical Pharmacology, Warsaw, Poland; Department of Medicine (J.-M.B.), Charles LeMoyne Hospital, University of Sherbrooke, Longueuil, Quebec; Department of Neurology (G.G.), Dalhousie University, Halifax, Nova Scotia, Canada; Department of Neurology (P.S., R.B.), All India Institute of Medical Sciences, New Delhi; Apollo Gleneagles Hospitals (J.R.), Kolkata, India; Department of Neurology (C.S.K.), Boston Medical Center; and Department of Neurology (A.D.W., C.D.A., M.E.G., S.M.G., A.V., J.R.), Henry and Allison McCance Center for Brain Health (J.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston.

Carlos A Molina (CA)

From the Ottawa Stroke Program (V.Y., D.D.), Department of Medicine (Neurology), Department of Radiology (C.L.), Ottawa Methods Center (T.R., D.F.), and Ottawa Hospital Research Institute (T.R., D.F., D.D.), University of Ottawa, Ontario; Calgary Stroke Program (A.M.D., M.D.H.), Department of Clinical Neurosciences, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta; Division of Neuroradiology and Department of Medical Imaging (R.I.A.), Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; Department of Neurology (D.R.-L., C.A.M.), Hospital Universitari Vall d'Hebron, Barcelona; Department of Neurology (Y.S.), Dr. Josep Trueta University Hospital, Institut d'Investigació Biomèdica Girona Foundation, Spain; Department of Neurology (I.D.), Elblandklinikum Meissen Academic Teaching Hospital of Technische University, Dresden, Germany; Interventional Stroke and Cerebrovascular Treatment Center and 2nd Department of Neurology (A.K.), Institute of Psychiatry and Neurology, and Department of Experimental and Clinical Pharmacology, Warsaw, Poland; Department of Medicine (J.-M.B.), Charles LeMoyne Hospital, University of Sherbrooke, Longueuil, Quebec; Department of Neurology (G.G.), Dalhousie University, Halifax, Nova Scotia, Canada; Department of Neurology (P.S., R.B.), All India Institute of Medical Sciences, New Delhi; Apollo Gleneagles Hospitals (J.R.), Kolkata, India; Department of Neurology (C.S.K.), Boston Medical Center; and Department of Neurology (A.D.W., C.D.A., M.E.G., S.M.G., A.V., J.R.), Henry and Allison McCance Center for Brain Health (J.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston.

Yolanda Silva (Y)

From the Ottawa Stroke Program (V.Y., D.D.), Department of Medicine (Neurology), Department of Radiology (C.L.), Ottawa Methods Center (T.R., D.F.), and Ottawa Hospital Research Institute (T.R., D.F., D.D.), University of Ottawa, Ontario; Calgary Stroke Program (A.M.D., M.D.H.), Department of Clinical Neurosciences, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta; Division of Neuroradiology and Department of Medical Imaging (R.I.A.), Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; Department of Neurology (D.R.-L., C.A.M.), Hospital Universitari Vall d'Hebron, Barcelona; Department of Neurology (Y.S.), Dr. Josep Trueta University Hospital, Institut d'Investigació Biomèdica Girona Foundation, Spain; Department of Neurology (I.D.), Elblandklinikum Meissen Academic Teaching Hospital of Technische University, Dresden, Germany; Interventional Stroke and Cerebrovascular Treatment Center and 2nd Department of Neurology (A.K.), Institute of Psychiatry and Neurology, and Department of Experimental and Clinical Pharmacology, Warsaw, Poland; Department of Medicine (J.-M.B.), Charles LeMoyne Hospital, University of Sherbrooke, Longueuil, Quebec; Department of Neurology (G.G.), Dalhousie University, Halifax, Nova Scotia, Canada; Department of Neurology (P.S., R.B.), All India Institute of Medical Sciences, New Delhi; Apollo Gleneagles Hospitals (J.R.), Kolkata, India; Department of Neurology (C.S.K.), Boston Medical Center; and Department of Neurology (A.D.W., C.D.A., M.E.G., S.M.G., A.V., J.R.), Henry and Allison McCance Center for Brain Health (J.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston.

Imanuel Dzialowski (I)

From the Ottawa Stroke Program (V.Y., D.D.), Department of Medicine (Neurology), Department of Radiology (C.L.), Ottawa Methods Center (T.R., D.F.), and Ottawa Hospital Research Institute (T.R., D.F., D.D.), University of Ottawa, Ontario; Calgary Stroke Program (A.M.D., M.D.H.), Department of Clinical Neurosciences, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta; Division of Neuroradiology and Department of Medical Imaging (R.I.A.), Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; Department of Neurology (D.R.-L., C.A.M.), Hospital Universitari Vall d'Hebron, Barcelona; Department of Neurology (Y.S.), Dr. Josep Trueta University Hospital, Institut d'Investigació Biomèdica Girona Foundation, Spain; Department of Neurology (I.D.), Elblandklinikum Meissen Academic Teaching Hospital of Technische University, Dresden, Germany; Interventional Stroke and Cerebrovascular Treatment Center and 2nd Department of Neurology (A.K.), Institute of Psychiatry and Neurology, and Department of Experimental and Clinical Pharmacology, Warsaw, Poland; Department of Medicine (J.-M.B.), Charles LeMoyne Hospital, University of Sherbrooke, Longueuil, Quebec; Department of Neurology (G.G.), Dalhousie University, Halifax, Nova Scotia, Canada; Department of Neurology (P.S., R.B.), All India Institute of Medical Sciences, New Delhi; Apollo Gleneagles Hospitals (J.R.), Kolkata, India; Department of Neurology (C.S.K.), Boston Medical Center; and Department of Neurology (A.D.W., C.D.A., M.E.G., S.M.G., A.V., J.R.), Henry and Allison McCance Center for Brain Health (J.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston.

Adam Kobayashi (A)

From the Ottawa Stroke Program (V.Y., D.D.), Department of Medicine (Neurology), Department of Radiology (C.L.), Ottawa Methods Center (T.R., D.F.), and Ottawa Hospital Research Institute (T.R., D.F., D.D.), University of Ottawa, Ontario; Calgary Stroke Program (A.M.D., M.D.H.), Department of Clinical Neurosciences, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta; Division of Neuroradiology and Department of Medical Imaging (R.I.A.), Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; Department of Neurology (D.R.-L., C.A.M.), Hospital Universitari Vall d'Hebron, Barcelona; Department of Neurology (Y.S.), Dr. Josep Trueta University Hospital, Institut d'Investigació Biomèdica Girona Foundation, Spain; Department of Neurology (I.D.), Elblandklinikum Meissen Academic Teaching Hospital of Technische University, Dresden, Germany; Interventional Stroke and Cerebrovascular Treatment Center and 2nd Department of Neurology (A.K.), Institute of Psychiatry and Neurology, and Department of Experimental and Clinical Pharmacology, Warsaw, Poland; Department of Medicine (J.-M.B.), Charles LeMoyne Hospital, University of Sherbrooke, Longueuil, Quebec; Department of Neurology (G.G.), Dalhousie University, Halifax, Nova Scotia, Canada; Department of Neurology (P.S., R.B.), All India Institute of Medical Sciences, New Delhi; Apollo Gleneagles Hospitals (J.R.), Kolkata, India; Department of Neurology (C.S.K.), Boston Medical Center; and Department of Neurology (A.D.W., C.D.A., M.E.G., S.M.G., A.V., J.R.), Henry and Allison McCance Center for Brain Health (J.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston.

Jean-Martin Boulanger (JM)

From the Ottawa Stroke Program (V.Y., D.D.), Department of Medicine (Neurology), Department of Radiology (C.L.), Ottawa Methods Center (T.R., D.F.), and Ottawa Hospital Research Institute (T.R., D.F., D.D.), University of Ottawa, Ontario; Calgary Stroke Program (A.M.D., M.D.H.), Department of Clinical Neurosciences, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta; Division of Neuroradiology and Department of Medical Imaging (R.I.A.), Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; Department of Neurology (D.R.-L., C.A.M.), Hospital Universitari Vall d'Hebron, Barcelona; Department of Neurology (Y.S.), Dr. Josep Trueta University Hospital, Institut d'Investigació Biomèdica Girona Foundation, Spain; Department of Neurology (I.D.), Elblandklinikum Meissen Academic Teaching Hospital of Technische University, Dresden, Germany; Interventional Stroke and Cerebrovascular Treatment Center and 2nd Department of Neurology (A.K.), Institute of Psychiatry and Neurology, and Department of Experimental and Clinical Pharmacology, Warsaw, Poland; Department of Medicine (J.-M.B.), Charles LeMoyne Hospital, University of Sherbrooke, Longueuil, Quebec; Department of Neurology (G.G.), Dalhousie University, Halifax, Nova Scotia, Canada; Department of Neurology (P.S., R.B.), All India Institute of Medical Sciences, New Delhi; Apollo Gleneagles Hospitals (J.R.), Kolkata, India; Department of Neurology (C.S.K.), Boston Medical Center; and Department of Neurology (A.D.W., C.D.A., M.E.G., S.M.G., A.V., J.R.), Henry and Allison McCance Center for Brain Health (J.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston.

Cheemun Lum (C)

From the Ottawa Stroke Program (V.Y., D.D.), Department of Medicine (Neurology), Department of Radiology (C.L.), Ottawa Methods Center (T.R., D.F.), and Ottawa Hospital Research Institute (T.R., D.F., D.D.), University of Ottawa, Ontario; Calgary Stroke Program (A.M.D., M.D.H.), Department of Clinical Neurosciences, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta; Division of Neuroradiology and Department of Medical Imaging (R.I.A.), Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; Department of Neurology (D.R.-L., C.A.M.), Hospital Universitari Vall d'Hebron, Barcelona; Department of Neurology (Y.S.), Dr. Josep Trueta University Hospital, Institut d'Investigació Biomèdica Girona Foundation, Spain; Department of Neurology (I.D.), Elblandklinikum Meissen Academic Teaching Hospital of Technische University, Dresden, Germany; Interventional Stroke and Cerebrovascular Treatment Center and 2nd Department of Neurology (A.K.), Institute of Psychiatry and Neurology, and Department of Experimental and Clinical Pharmacology, Warsaw, Poland; Department of Medicine (J.-M.B.), Charles LeMoyne Hospital, University of Sherbrooke, Longueuil, Quebec; Department of Neurology (G.G.), Dalhousie University, Halifax, Nova Scotia, Canada; Department of Neurology (P.S., R.B.), All India Institute of Medical Sciences, New Delhi; Apollo Gleneagles Hospitals (J.R.), Kolkata, India; Department of Neurology (C.S.K.), Boston Medical Center; and Department of Neurology (A.D.W., C.D.A., M.E.G., S.M.G., A.V., J.R.), Henry and Allison McCance Center for Brain Health (J.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston.

Gord Gubitz (G)

From the Ottawa Stroke Program (V.Y., D.D.), Department of Medicine (Neurology), Department of Radiology (C.L.), Ottawa Methods Center (T.R., D.F.), and Ottawa Hospital Research Institute (T.R., D.F., D.D.), University of Ottawa, Ontario; Calgary Stroke Program (A.M.D., M.D.H.), Department of Clinical Neurosciences, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta; Division of Neuroradiology and Department of Medical Imaging (R.I.A.), Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; Department of Neurology (D.R.-L., C.A.M.), Hospital Universitari Vall d'Hebron, Barcelona; Department of Neurology (Y.S.), Dr. Josep Trueta University Hospital, Institut d'Investigació Biomèdica Girona Foundation, Spain; Department of Neurology (I.D.), Elblandklinikum Meissen Academic Teaching Hospital of Technische University, Dresden, Germany; Interventional Stroke and Cerebrovascular Treatment Center and 2nd Department of Neurology (A.K.), Institute of Psychiatry and Neurology, and Department of Experimental and Clinical Pharmacology, Warsaw, Poland; Department of Medicine (J.-M.B.), Charles LeMoyne Hospital, University of Sherbrooke, Longueuil, Quebec; Department of Neurology (G.G.), Dalhousie University, Halifax, Nova Scotia, Canada; Department of Neurology (P.S., R.B.), All India Institute of Medical Sciences, New Delhi; Apollo Gleneagles Hospitals (J.R.), Kolkata, India; Department of Neurology (C.S.K.), Boston Medical Center; and Department of Neurology (A.D.W., C.D.A., M.E.G., S.M.G., A.V., J.R.), Henry and Allison McCance Center for Brain Health (J.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston.

Padma Srivastava (P)

From the Ottawa Stroke Program (V.Y., D.D.), Department of Medicine (Neurology), Department of Radiology (C.L.), Ottawa Methods Center (T.R., D.F.), and Ottawa Hospital Research Institute (T.R., D.F., D.D.), University of Ottawa, Ontario; Calgary Stroke Program (A.M.D., M.D.H.), Department of Clinical Neurosciences, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta; Division of Neuroradiology and Department of Medical Imaging (R.I.A.), Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; Department of Neurology (D.R.-L., C.A.M.), Hospital Universitari Vall d'Hebron, Barcelona; Department of Neurology (Y.S.), Dr. Josep Trueta University Hospital, Institut d'Investigació Biomèdica Girona Foundation, Spain; Department of Neurology (I.D.), Elblandklinikum Meissen Academic Teaching Hospital of Technische University, Dresden, Germany; Interventional Stroke and Cerebrovascular Treatment Center and 2nd Department of Neurology (A.K.), Institute of Psychiatry and Neurology, and Department of Experimental and Clinical Pharmacology, Warsaw, Poland; Department of Medicine (J.-M.B.), Charles LeMoyne Hospital, University of Sherbrooke, Longueuil, Quebec; Department of Neurology (G.G.), Dalhousie University, Halifax, Nova Scotia, Canada; Department of Neurology (P.S., R.B.), All India Institute of Medical Sciences, New Delhi; Apollo Gleneagles Hospitals (J.R.), Kolkata, India; Department of Neurology (C.S.K.), Boston Medical Center; and Department of Neurology (A.D.W., C.D.A., M.E.G., S.M.G., A.V., J.R.), Henry and Allison McCance Center for Brain Health (J.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston.

Jayanta Roy (J)

From the Ottawa Stroke Program (V.Y., D.D.), Department of Medicine (Neurology), Department of Radiology (C.L.), Ottawa Methods Center (T.R., D.F.), and Ottawa Hospital Research Institute (T.R., D.F., D.D.), University of Ottawa, Ontario; Calgary Stroke Program (A.M.D., M.D.H.), Department of Clinical Neurosciences, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta; Division of Neuroradiology and Department of Medical Imaging (R.I.A.), Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; Department of Neurology (D.R.-L., C.A.M.), Hospital Universitari Vall d'Hebron, Barcelona; Department of Neurology (Y.S.), Dr. Josep Trueta University Hospital, Institut d'Investigació Biomèdica Girona Foundation, Spain; Department of Neurology (I.D.), Elblandklinikum Meissen Academic Teaching Hospital of Technische University, Dresden, Germany; Interventional Stroke and Cerebrovascular Treatment Center and 2nd Department of Neurology (A.K.), Institute of Psychiatry and Neurology, and Department of Experimental and Clinical Pharmacology, Warsaw, Poland; Department of Medicine (J.-M.B.), Charles LeMoyne Hospital, University of Sherbrooke, Longueuil, Quebec; Department of Neurology (G.G.), Dalhousie University, Halifax, Nova Scotia, Canada; Department of Neurology (P.S., R.B.), All India Institute of Medical Sciences, New Delhi; Apollo Gleneagles Hospitals (J.R.), Kolkata, India; Department of Neurology (C.S.K.), Boston Medical Center; and Department of Neurology (A.D.W., C.D.A., M.E.G., S.M.G., A.V., J.R.), Henry and Allison McCance Center for Brain Health (J.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston.

Carlos S Kase (CS)

From the Ottawa Stroke Program (V.Y., D.D.), Department of Medicine (Neurology), Department of Radiology (C.L.), Ottawa Methods Center (T.R., D.F.), and Ottawa Hospital Research Institute (T.R., D.F., D.D.), University of Ottawa, Ontario; Calgary Stroke Program (A.M.D., M.D.H.), Department of Clinical Neurosciences, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta; Division of Neuroradiology and Department of Medical Imaging (R.I.A.), Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; Department of Neurology (D.R.-L., C.A.M.), Hospital Universitari Vall d'Hebron, Barcelona; Department of Neurology (Y.S.), Dr. Josep Trueta University Hospital, Institut d'Investigació Biomèdica Girona Foundation, Spain; Department of Neurology (I.D.), Elblandklinikum Meissen Academic Teaching Hospital of Technische University, Dresden, Germany; Interventional Stroke and Cerebrovascular Treatment Center and 2nd Department of Neurology (A.K.), Institute of Psychiatry and Neurology, and Department of Experimental and Clinical Pharmacology, Warsaw, Poland; Department of Medicine (J.-M.B.), Charles LeMoyne Hospital, University of Sherbrooke, Longueuil, Quebec; Department of Neurology (G.G.), Dalhousie University, Halifax, Nova Scotia, Canada; Department of Neurology (P.S., R.B.), All India Institute of Medical Sciences, New Delhi; Apollo Gleneagles Hospitals (J.R.), Kolkata, India; Department of Neurology (C.S.K.), Boston Medical Center; and Department of Neurology (A.D.W., C.D.A., M.E.G., S.M.G., A.V., J.R.), Henry and Allison McCance Center for Brain Health (J.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston.

Rohit Bhatia (R)

From the Ottawa Stroke Program (V.Y., D.D.), Department of Medicine (Neurology), Department of Radiology (C.L.), Ottawa Methods Center (T.R., D.F.), and Ottawa Hospital Research Institute (T.R., D.F., D.D.), University of Ottawa, Ontario; Calgary Stroke Program (A.M.D., M.D.H.), Department of Clinical Neurosciences, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta; Division of Neuroradiology and Department of Medical Imaging (R.I.A.), Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; Department of Neurology (D.R.-L., C.A.M.), Hospital Universitari Vall d'Hebron, Barcelona; Department of Neurology (Y.S.), Dr. Josep Trueta University Hospital, Institut d'Investigació Biomèdica Girona Foundation, Spain; Department of Neurology (I.D.), Elblandklinikum Meissen Academic Teaching Hospital of Technische University, Dresden, Germany; Interventional Stroke and Cerebrovascular Treatment Center and 2nd Department of Neurology (A.K.), Institute of Psychiatry and Neurology, and Department of Experimental and Clinical Pharmacology, Warsaw, Poland; Department of Medicine (J.-M.B.), Charles LeMoyne Hospital, University of Sherbrooke, Longueuil, Quebec; Department of Neurology (G.G.), Dalhousie University, Halifax, Nova Scotia, Canada; Department of Neurology (P.S., R.B.), All India Institute of Medical Sciences, New Delhi; Apollo Gleneagles Hospitals (J.R.), Kolkata, India; Department of Neurology (C.S.K.), Boston Medical Center; and Department of Neurology (A.D.W., C.D.A., M.E.G., S.M.G., A.V., J.R.), Henry and Allison McCance Center for Brain Health (J.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston.

Michael D Hill (MD)

From the Ottawa Stroke Program (V.Y., D.D.), Department of Medicine (Neurology), Department of Radiology (C.L.), Ottawa Methods Center (T.R., D.F.), and Ottawa Hospital Research Institute (T.R., D.F., D.D.), University of Ottawa, Ontario; Calgary Stroke Program (A.M.D., M.D.H.), Department of Clinical Neurosciences, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta; Division of Neuroradiology and Department of Medical Imaging (R.I.A.), Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; Department of Neurology (D.R.-L., C.A.M.), Hospital Universitari Vall d'Hebron, Barcelona; Department of Neurology (Y.S.), Dr. Josep Trueta University Hospital, Institut d'Investigació Biomèdica Girona Foundation, Spain; Department of Neurology (I.D.), Elblandklinikum Meissen Academic Teaching Hospital of Technische University, Dresden, Germany; Interventional Stroke and Cerebrovascular Treatment Center and 2nd Department of Neurology (A.K.), Institute of Psychiatry and Neurology, and Department of Experimental and Clinical Pharmacology, Warsaw, Poland; Department of Medicine (J.-M.B.), Charles LeMoyne Hospital, University of Sherbrooke, Longueuil, Quebec; Department of Neurology (G.G.), Dalhousie University, Halifax, Nova Scotia, Canada; Department of Neurology (P.S., R.B.), All India Institute of Medical Sciences, New Delhi; Apollo Gleneagles Hospitals (J.R.), Kolkata, India; Department of Neurology (C.S.K.), Boston Medical Center; and Department of Neurology (A.D.W., C.D.A., M.E.G., S.M.G., A.V., J.R.), Henry and Allison McCance Center for Brain Health (J.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston.
ORCID: 0000-0002-6269-1543

Andrew D Warren (AD)

From the Ottawa Stroke Program (V.Y., D.D.), Department of Medicine (Neurology), Department of Radiology (C.L.), Ottawa Methods Center (T.R., D.F.), and Ottawa Hospital Research Institute (T.R., D.F., D.D.), University of Ottawa, Ontario; Calgary Stroke Program (A.M.D., M.D.H.), Department of Clinical Neurosciences, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta; Division of Neuroradiology and Department of Medical Imaging (R.I.A.), Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; Department of Neurology (D.R.-L., C.A.M.), Hospital Universitari Vall d'Hebron, Barcelona; Department of Neurology (Y.S.), Dr. Josep Trueta University Hospital, Institut d'Investigació Biomèdica Girona Foundation, Spain; Department of Neurology (I.D.), Elblandklinikum Meissen Academic Teaching Hospital of Technische University, Dresden, Germany; Interventional Stroke and Cerebrovascular Treatment Center and 2nd Department of Neurology (A.K.), Institute of Psychiatry and Neurology, and Department of Experimental and Clinical Pharmacology, Warsaw, Poland; Department of Medicine (J.-M.B.), Charles LeMoyne Hospital, University of Sherbrooke, Longueuil, Quebec; Department of Neurology (G.G.), Dalhousie University, Halifax, Nova Scotia, Canada; Department of Neurology (P.S., R.B.), All India Institute of Medical Sciences, New Delhi; Apollo Gleneagles Hospitals (J.R.), Kolkata, India; Department of Neurology (C.S.K.), Boston Medical Center; and Department of Neurology (A.D.W., C.D.A., M.E.G., S.M.G., A.V., J.R.), Henry and Allison McCance Center for Brain Health (J.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston.

Christopher D Anderson (CD)

From the Ottawa Stroke Program (V.Y., D.D.), Department of Medicine (Neurology), Department of Radiology (C.L.), Ottawa Methods Center (T.R., D.F.), and Ottawa Hospital Research Institute (T.R., D.F., D.D.), University of Ottawa, Ontario; Calgary Stroke Program (A.M.D., M.D.H.), Department of Clinical Neurosciences, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta; Division of Neuroradiology and Department of Medical Imaging (R.I.A.), Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; Department of Neurology (D.R.-L., C.A.M.), Hospital Universitari Vall d'Hebron, Barcelona; Department of Neurology (Y.S.), Dr. Josep Trueta University Hospital, Institut d'Investigació Biomèdica Girona Foundation, Spain; Department of Neurology (I.D.), Elblandklinikum Meissen Academic Teaching Hospital of Technische University, Dresden, Germany; Interventional Stroke and Cerebrovascular Treatment Center and 2nd Department of Neurology (A.K.), Institute of Psychiatry and Neurology, and Department of Experimental and Clinical Pharmacology, Warsaw, Poland; Department of Medicine (J.-M.B.), Charles LeMoyne Hospital, University of Sherbrooke, Longueuil, Quebec; Department of Neurology (G.G.), Dalhousie University, Halifax, Nova Scotia, Canada; Department of Neurology (P.S., R.B.), All India Institute of Medical Sciences, New Delhi; Apollo Gleneagles Hospitals (J.R.), Kolkata, India; Department of Neurology (C.S.K.), Boston Medical Center; and Department of Neurology (A.D.W., C.D.A., M.E.G., S.M.G., A.V., J.R.), Henry and Allison McCance Center for Brain Health (J.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston.

Mahmut E Gurol (ME)

From the Ottawa Stroke Program (V.Y., D.D.), Department of Medicine (Neurology), Department of Radiology (C.L.), Ottawa Methods Center (T.R., D.F.), and Ottawa Hospital Research Institute (T.R., D.F., D.D.), University of Ottawa, Ontario; Calgary Stroke Program (A.M.D., M.D.H.), Department of Clinical Neurosciences, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta; Division of Neuroradiology and Department of Medical Imaging (R.I.A.), Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; Department of Neurology (D.R.-L., C.A.M.), Hospital Universitari Vall d'Hebron, Barcelona; Department of Neurology (Y.S.), Dr. Josep Trueta University Hospital, Institut d'Investigació Biomèdica Girona Foundation, Spain; Department of Neurology (I.D.), Elblandklinikum Meissen Academic Teaching Hospital of Technische University, Dresden, Germany; Interventional Stroke and Cerebrovascular Treatment Center and 2nd Department of Neurology (A.K.), Institute of Psychiatry and Neurology, and Department of Experimental and Clinical Pharmacology, Warsaw, Poland; Department of Medicine (J.-M.B.), Charles LeMoyne Hospital, University of Sherbrooke, Longueuil, Quebec; Department of Neurology (G.G.), Dalhousie University, Halifax, Nova Scotia, Canada; Department of Neurology (P.S., R.B.), All India Institute of Medical Sciences, New Delhi; Apollo Gleneagles Hospitals (J.R.), Kolkata, India; Department of Neurology (C.S.K.), Boston Medical Center; and Department of Neurology (A.D.W., C.D.A., M.E.G., S.M.G., A.V., J.R.), Henry and Allison McCance Center for Brain Health (J.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston.

Steve M Greenberg (SM)

From the Ottawa Stroke Program (V.Y., D.D.), Department of Medicine (Neurology), Department of Radiology (C.L.), Ottawa Methods Center (T.R., D.F.), and Ottawa Hospital Research Institute (T.R., D.F., D.D.), University of Ottawa, Ontario; Calgary Stroke Program (A.M.D., M.D.H.), Department of Clinical Neurosciences, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta; Division of Neuroradiology and Department of Medical Imaging (R.I.A.), Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; Department of Neurology (D.R.-L., C.A.M.), Hospital Universitari Vall d'Hebron, Barcelona; Department of Neurology (Y.S.), Dr. Josep Trueta University Hospital, Institut d'Investigació Biomèdica Girona Foundation, Spain; Department of Neurology (I.D.), Elblandklinikum Meissen Academic Teaching Hospital of Technische University, Dresden, Germany; Interventional Stroke and Cerebrovascular Treatment Center and 2nd Department of Neurology (A.K.), Institute of Psychiatry and Neurology, and Department of Experimental and Clinical Pharmacology, Warsaw, Poland; Department of Medicine (J.-M.B.), Charles LeMoyne Hospital, University of Sherbrooke, Longueuil, Quebec; Department of Neurology (G.G.), Dalhousie University, Halifax, Nova Scotia, Canada; Department of Neurology (P.S., R.B.), All India Institute of Medical Sciences, New Delhi; Apollo Gleneagles Hospitals (J.R.), Kolkata, India; Department of Neurology (C.S.K.), Boston Medical Center; and Department of Neurology (A.D.W., C.D.A., M.E.G., S.M.G., A.V., J.R.), Henry and Allison McCance Center for Brain Health (J.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston.

Anand Viswanathan (A)

From the Ottawa Stroke Program (V.Y., D.D.), Department of Medicine (Neurology), Department of Radiology (C.L.), Ottawa Methods Center (T.R., D.F.), and Ottawa Hospital Research Institute (T.R., D.F., D.D.), University of Ottawa, Ontario; Calgary Stroke Program (A.M.D., M.D.H.), Department of Clinical Neurosciences, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta; Division of Neuroradiology and Department of Medical Imaging (R.I.A.), Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; Department of Neurology (D.R.-L., C.A.M.), Hospital Universitari Vall d'Hebron, Barcelona; Department of Neurology (Y.S.), Dr. Josep Trueta University Hospital, Institut d'Investigació Biomèdica Girona Foundation, Spain; Department of Neurology (I.D.), Elblandklinikum Meissen Academic Teaching Hospital of Technische University, Dresden, Germany; Interventional Stroke and Cerebrovascular Treatment Center and 2nd Department of Neurology (A.K.), Institute of Psychiatry and Neurology, and Department of Experimental and Clinical Pharmacology, Warsaw, Poland; Department of Medicine (J.-M.B.), Charles LeMoyne Hospital, University of Sherbrooke, Longueuil, Quebec; Department of Neurology (G.G.), Dalhousie University, Halifax, Nova Scotia, Canada; Department of Neurology (P.S., R.B.), All India Institute of Medical Sciences, New Delhi; Apollo Gleneagles Hospitals (J.R.), Kolkata, India; Department of Neurology (C.S.K.), Boston Medical Center; and Department of Neurology (A.D.W., C.D.A., M.E.G., S.M.G., A.V., J.R.), Henry and Allison McCance Center for Brain Health (J.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston.

Jonathan Rosand (J)

From the Ottawa Stroke Program (V.Y., D.D.), Department of Medicine (Neurology), Department of Radiology (C.L.), Ottawa Methods Center (T.R., D.F.), and Ottawa Hospital Research Institute (T.R., D.F., D.D.), University of Ottawa, Ontario; Calgary Stroke Program (A.M.D., M.D.H.), Department of Clinical Neurosciences, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta; Division of Neuroradiology and Department of Medical Imaging (R.I.A.), Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; Department of Neurology (D.R.-L., C.A.M.), Hospital Universitari Vall d'Hebron, Barcelona; Department of Neurology (Y.S.), Dr. Josep Trueta University Hospital, Institut d'Investigació Biomèdica Girona Foundation, Spain; Department of Neurology (I.D.), Elblandklinikum Meissen Academic Teaching Hospital of Technische University, Dresden, Germany; Interventional Stroke and Cerebrovascular Treatment Center and 2nd Department of Neurology (A.K.), Institute of Psychiatry and Neurology, and Department of Experimental and Clinical Pharmacology, Warsaw, Poland; Department of Medicine (J.-M.B.), Charles LeMoyne Hospital, University of Sherbrooke, Longueuil, Quebec; Department of Neurology (G.G.), Dalhousie University, Halifax, Nova Scotia, Canada; Department of Neurology (P.S., R.B.), All India Institute of Medical Sciences, New Delhi; Apollo Gleneagles Hospitals (J.R.), Kolkata, India; Department of Neurology (C.S.K.), Boston Medical Center; and Department of Neurology (A.D.W., C.D.A., M.E.G., S.M.G., A.V., J.R.), Henry and Allison McCance Center for Brain Health (J.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston.

Joshua N Goldstein (JN)

From the Ottawa Stroke Program (V.Y., D.D.), Department of Medicine (Neurology), Department of Radiology (C.L.), Ottawa Methods Center (T.R., D.F.), and Ottawa Hospital Research Institute (T.R., D.F., D.D.), University of Ottawa, Ontario; Calgary Stroke Program (A.M.D., M.D.H.), Department of Clinical Neurosciences, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta; Division of Neuroradiology and Department of Medical Imaging (R.I.A.), Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; Department of Neurology (D.R.-L., C.A.M.), Hospital Universitari Vall d'Hebron, Barcelona; Department of Neurology (Y.S.), Dr. Josep Trueta University Hospital, Institut d'Investigació Biomèdica Girona Foundation, Spain; Department of Neurology (I.D.), Elblandklinikum Meissen Academic Teaching Hospital of Technische University, Dresden, Germany; Interventional Stroke and Cerebrovascular Treatment Center and 2nd Department of Neurology (A.K.), Institute of Psychiatry and Neurology, and Department of Experimental and Clinical Pharmacology, Warsaw, Poland; Department of Medicine (J.-M.B.), Charles LeMoyne Hospital, University of Sherbrooke, Longueuil, Quebec; Department of Neurology (G.G.), Dalhousie University, Halifax, Nova Scotia, Canada; Department of Neurology (P.S., R.B.), All India Institute of Medical Sciences, New Delhi; Apollo Gleneagles Hospitals (J.R.), Kolkata, India; Department of Neurology (C.S.K.), Boston Medical Center; and Department of Neurology (A.D.W., C.D.A., M.E.G., S.M.G., A.V., J.R.), Henry and Allison McCance Center for Brain Health (J.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston.

Dar Dowlatshahi (D)

From the Ottawa Stroke Program (V.Y., D.D.), Department of Medicine (Neurology), Department of Radiology (C.L.), Ottawa Methods Center (T.R., D.F.), and Ottawa Hospital Research Institute (T.R., D.F., D.D.), University of Ottawa, Ontario; Calgary Stroke Program (A.M.D., M.D.H.), Department of Clinical Neurosciences, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta; Division of Neuroradiology and Department of Medical Imaging (R.I.A.), Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; Department of Neurology (D.R.-L., C.A.M.), Hospital Universitari Vall d'Hebron, Barcelona; Department of Neurology (Y.S.), Dr. Josep Trueta University Hospital, Institut d'Investigació Biomèdica Girona Foundation, Spain; Department of Neurology (I.D.), Elblandklinikum Meissen Academic Teaching Hospital of Technische University, Dresden, Germany; Interventional Stroke and Cerebrovascular Treatment Center and 2nd Department of Neurology (A.K.), Institute of Psychiatry and Neurology, and Department of Experimental and Clinical Pharmacology, Warsaw, Poland; Department of Medicine (J.-M.B.), Charles LeMoyne Hospital, University of Sherbrooke, Longueuil, Quebec; Department of Neurology (G.G.), Dalhousie University, Halifax, Nova Scotia, Canada; Department of Neurology (P.S., R.B.), All India Institute of Medical Sciences, New Delhi; Apollo Gleneagles Hospitals (J.R.), Kolkata, India; Department of Neurology (C.S.K.), Boston Medical Center; and Department of Neurology (A.D.W., C.D.A., M.E.G., S.M.G., A.V., J.R.), Henry and Allison McCance Center for Brain Health (J.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › New and expanding ventricular hemorrhage...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › New and expanding ventricular hemorrhage...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Hémorragie › Hémorragies intracrâniennes › Hémorragie cérébrale › New and expanding ventricular hemorrhage...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Ventricules cérébraux › New and expanding ventricular hemorrhage...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › New and expanding ventricular hemorrhage...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › New and expanding ventricular hemorrhage...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de régression › Modèles linéaires › New and expanding ventricular hemorrhage...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › New and expanding ventricular hemorrhage...
questionsmedicales.fr › Disciplines des sciences naturelles › Mathématiques › Dynamique non linéaire › New and expanding ventricular hemorrhage...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › New and expanding ventricular hemorrhage...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Tomographie à rayons X › Tomodensitométrie › New and expanding ventricular hemorrhage...