Data showing atherosclerosis-associated differentially methylated regions are often at enhancers.
Atherosclerosis
DMR, differentially methylated region
DNA methylation
Differentially methylated regions (DMRs)
Enhancers
GO, gene ontology
Monocytes
PBMC, peripheral blood mononuclear cells
PMD, percent methylation difference
SkM, skeletal muscle
Smooth muscle
athero hypermeth DMR, atherosclerosis-associated hypermethylated DMR
athero hypometh DMR, atherosclerosis-associated hypomethylated DMR
ctl, control
enh, enhancer chromatin
mod, moderate
prom, promoter chromatin
repr, repressed
txn chromatin, chromatin with the histone marks of actively transcribed chromatin
Journal
Data in brief
ISSN: 2352-3409
Titre abrégé: Data Brief
Pays: Netherlands
ID NLM: 101654995
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
30
01
2019
revised:
22
02
2019
accepted:
26
02
2019
entrez:
3
8
2019
pubmed:
3
8
2019
medline:
3
8
2019
Statut:
epublish
Résumé
Atherosclerosis involves phenotypic modulation and transdifferentiation of vascular smooth muscle cells (SMCs). Data are given in tabular or figure format that illustrate genome-wide DNA methylation alterations in atherosclerotic vs. control aorta (athero DMRs). Data based upon publicly available chromatin state profiles are also shown for normal aorta, monocyte, and skeletal muscle tissue-specific DMRs and for aorta-specific chromatin features (enhancer chromatin, promoter chromatin, repressed chromatin, actively transcribed chromatin). Athero hypomethylated and hypermethylated DMRs as well as epigenetic and transcription profiles are described for the following genes:
Identifiants
pubmed: 31372457
doi: 10.1016/j.dib.2019.103812
pii: S2352-3409(19)30163-5
pii: 103812
pmc: PMC6660590
doi:
Types de publication
Journal Article
Langues
eng
Pagination
103812Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001417
Pays : United States
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