Reparative macrophage transplantation for myocardial repair: a refinement of bone marrow mononuclear cell-based therapy.
Cell therapy
Inflammation
Macrophages
Myocardial infarction
Myocardial repair
Journal
Basic research in cardiology
ISSN: 1435-1803
Titre abrégé: Basic Res Cardiol
Pays: Germany
ID NLM: 0360342
Informations de publication
Date de publication:
01 08 2019
01 08 2019
Historique:
received:
20
05
2019
accepted:
23
07
2019
entrez:
3
8
2019
pubmed:
3
8
2019
medline:
11
2
2020
Statut:
epublish
Résumé
Reparative macrophages play an important role in cardiac repair post-myocardial infarction (MI). Bone marrow mononuclear cells (BM-MNCs) have been investigated as a donor for cell therapy but with limited clinical success. These cells, however, may be utilized as a source for reparative macrophages. This translational study aimed to establish a robust in vitro protocol to produce functional reparative macrophages from BM-MNCs and to establish pre-clinical evidence of the efficacy of reparative macrophage transplantation for the treatment of MI. Mouse BM-MNCs were treated with M-CSF plus IL-4, IL-10, TGF-β1 or combinations of these in vitro. The concomitant administration of M-CSF and IL-4 produced the highest rate and largest number of CD11b
Identifiants
pubmed: 31372765
doi: 10.1007/s00395-019-0742-1
pii: 10.1007/s00395-019-0742-1
pmc: PMC6675756
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
34Subventions
Organisme : British Heart Foundation
ID : PG/18/77/34100
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/15/3/31236
Pays : United Kingdom
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