Efficacy of topical Citrullus colocynthis (bitter apple) extract oil in chemotherapy-induced peripheral neuropathy: A pilot double-blind randomized placebo-controlled clinical trial.
Journal
Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
11
11
2018
revised:
17
06
2019
accepted:
26
06
2019
pubmed:
3
8
2019
medline:
27
12
2019
entrez:
3
8
2019
Statut:
ppublish
Résumé
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common complications in patients with cancer. Citrullus colocynthis (bitter apple) has been used in traditional Persian medicine as an effective pain relief, especially for neuralgia. We designed a pilot clinical trial to evaluate the safety and efficacy of topical C. colocynthis oil in management of CIPN in breast cancer patients. Thirty-four cancer patients with CIPN were randomly enrolled in two arms of a randomized, double-blind, placebo-controlled clinical trial. The patients were treated by topical C. colocynthis oil or placebo, two times per day for 2 months. Functional Assessment of Cancer Therapy/Gynecologic Oncology Group (FACT/GOG)-Neurotoxicity (Ntx) score was set as the primary outcome measure. No significant improvement was observed in the total score of FACT/GOG-Ntx scale (2.40 ± 1.90 vs. 1.05 ± 1.36, p = .879) in drug and placebo groups, respectively. There was also no significant improvement in the mean scores of FACT/GOG-Ntx in the sensory, motor, hearing, and functional domains in the two study groups. According to the results of this preliminary study, topical C. colocynthis oil failed to improve the symptoms of CIPN compared with placebo.
Substances chimiques
Antineoplastic Agents
0
Plant Extracts
0
Plant Oils
0
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
2685-2691Informations de copyright
© 2019 John Wiley & Sons, Ltd.
Références
Akbari, A., Nasiri, K., Heydari, M., Mosavat, S. H., & Iraji, A. (2017). The protective effect of hydroalcoholic extract of Zingiber officinale Roscoe (Ginger) on ethanol-induced reproductive toxicity in male rats. Journal of Evidence-Based Complementary & Alternative Medicine, 22(4), 609-617. https://doi.org/10.1177/2156587216687696
Andrew, R., & Izzo, A. A. (2017). Principles of pharmacological research of nutraceuticals. British Journal of Pharmacology, 174(11), 1177-1194. https://doi.org/10.1111/bph.13779
Argyriou, A. A., Bruna, J., Marmiroli, P., & Cavaletti, G. (2012). Chemotherapy-induced peripheral neurotoxicity (CIPN): An update. Critical Reviews in Oncology/Hematology, 82(1), 51-77. https://doi.org/10.1016/j.critrevonc.2011.04.012
Brami, C., Bao, T., & Deng, G. (2016). Natural products and complementary therapies for chemotherapy-induced peripheral neuropathy: A systematic review. Critical Reviews in Oncology/Hematology, 98, 325-334. https://doi.org/10.1016/j.critrevonc.2015.11.014
Dorchin, M., Dehshiri, R. M., Soleiman, S., & Manashi, M. (2013). Evaluation of neuropathy during intensive vincristine chemotherapy for non-Hodgkin's lymphoma and acute lymphoblastic leukemia. Iranian Journal of Pediatric Hematology and Oncology., 3(4), 138-142.
Ewertz, M., Qvortrup, C., & Eckhoff, L. (2015). Chemotherapy-induced peripheral neuropathy in patients treated with taxanes and platinum derivatives. Acta Oncologica, 54(5), 587-591. https://doi.org/10.3109/0284186X.2014.995775
Farshchian, N., Alavi, A., Heydarheydari, S., & Moradian, N. (2018). Comparative study of the effects of venlafaxine and duloxetine on chemotherapy-induced peripheral neuropathy. Cancer Chemotherapy and Pharmacology, 82(5), 787-793. https://doi.org/10.1007/s00280-018-3664-y
for the Alliance for Clinical Trials in Oncology, Lavoie Smith, E. M., Pang, H., Cirrincione, C., Fleishman, S., Paskett, E. D., … Shapiro, C. L. (2013). Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: A randomized clinical trial. Journal of the American Medical Association, 309(13), 1359-1367. https://doi.org/10.1001/jama.2013.2813
Ghoreishi, Z., Esfahani, A., Djazayeri, A., Djalali, M., Golestan, B., Ayromlou, H., … Darabi, M. (2012). Omega-3 fatty acids are protective against paclitaxel-induced peripheral neuropathy: A randomized double-blind placebo controlled trial. BMC Cancer, 12(1), 355. https://doi.org/10.1186/1471-2407-12-355
Han, Y., & Smith, M. T. (2013). Pathobiology of cancer chemotherapy-induced peripheral neuropathy (CIPN). Frontiers in Pharmacology, 4, 156.
Hashempur, M. H., Ghasemi, M. S., Daneshfard, B., Ghoreishi, P. S., Lari, Z. N., Homayouni, K., & Zargaran, A. (2017). Efficacy of topical chamomile oil for mild and moderate carpal tunnel syndrome: A randomized double-blind placebo-controlled clinical trial. Complementary Therapies in Clinical Practice, 26, 61-67. https://doi.org/10.1016/j.ctcp.2016.11.010
Heydari, M., Homayouni, K., Hashempur, M. H., & Shams, M. (2016). Topical Citrullus colocynthis (bitter apple) extract oil in painful diabetic neuropathy: A double-blind randomized placebo-controlled clinical trial: 外用西瓜属药西瓜瓤 (苦苹果) 提取油治疗痛性糖尿病神经病变: 一项双盲随机安慰剂对照的临床试验. Journal of Diabetes, 8(2), 246-252. https://doi.org/10.1111/1753-0407.12287
Heydari, M., Shams, M., Homayouni, K., Borhani-Haghighi, A., Salehi, A., & Hashempur, M. H. (2014). An option for painful diabetic neuropathy with simultaneous ‘antioxidative’ and ‘anesthetic’ properties: Topical Citrullus colocynthis. Journal of Experimental and Integrative Medicine, 4(1), 9-12. https://doi.org/10.5455/jeim.031113.hp.009
Hunter, P. M., & Hegele, R. A. (2017). Functional foods and dietary supplements for the management of dyslipidaemia. Nature Reviews Endocrinology, 13(5), 278-288. https://doi.org/10.1038/nrendo.2016.210
Huseini, H. F., Darvishzadeh, F., Heshmat, R., Jafariazar, Z., Raza, M., & Larijani, B. (2009). The clinical investigation of Citrullus colocynthis (L.) schrad fruit in treatment of Type II diabetic patients: A randomized, double blind, placebo-controlled clinical trial. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 23(8), 1186-1189. https://doi.org/10.1002/ptr.2754
Hussain, A. I., Rathore, H. A., Sattar, M. Z., Chatha, S. A., Sarker, S. D., & Gilani, A. H. (2014). Citrullus colocynthis (L.) Schrad (bitter apple fruit): A review of its phytochemistry, pharmacology, traditional uses and nutritional potential. Journal of Ethnopharmacology, 155(1), 54-66. https://doi.org/10.1016/j.jep.2014.06.011
Loprinzi CL. Prevention and treatment of chemotherapy-induced peripheral neuropathy. UpToDate Retrieved from http://www.uptodate.com/home/index.html. 2017.
Majithia, N., Loprinzi, C. L., & Smith, T. J. (2016). New practical approaches to chemotherapy-induced neuropathic pain: Prevention, assessment, and treatment. Oncology, 30(11), 1020-1029.
McWhinney, S. R., Goldberg, R. M., & McLeod, H. L. (2009). Platinum neurotoxicity pharmacogenetics. Molecular Cancer Therapeutics, 8(1), 10-16. https://doi.org/10.1158/1535-7163.MCT-08-0840
Mehrzadi, S., Shojaii, A., Pur, S. A., & Motevalian, M. (2016). Anticonvulsant activity of hydroalcoholic extract of Citrullus colocynthis fruit: Involvement of benzodiazepine and opioid receptors. Journal of Evidence-Based Complementary & Alternative Medicine, 21(4), NP31-NP35. https://doi.org/10.1177/2156587215615455
Minuz, P., Velo, G., Violi, F., & Ferro, A. (2017). Are nutraceuticals the modern panacea? From myth to science. British Journal of Clinical Pharmacology, 83(1), 5-7. https://doi.org/10.1111/bcp.13142
Mosavat, S. H., Ghahramani, L., Sobhani, Z., Haghighi, E. R., Chaijan, M. R., & Heydari, M. (2015). The effect of leek (Allium iranicum (Wendelbo)) leaves extract cream on hemorrhoid patients: A double blind randomized controlled clinical trial. European Journal of Integrative Medicine, 7(6), 669-673. https://doi.org/10.1016/j.eujim.2015.08.008
Noh, H., & Yoon, S. W. (2018). A systematic review of herbal medicine for chemotherapy induced peripheral neuropathy. Evidence-Based Complementary and Alternative Medicine, 2018, 6194184.
Nouri, M. H. K., & Abad, A. N. A. (2012). Antinociceptive effect of Matricaria chamomilla on vincristine-induced peripheral neuropathy in mice. African Journal of Pharmacy and Pharmacology, 6(1), 24-29. https://doi.org/10.5897/AJPP11.340
Ostadhadi, S., Rahmatollahi, M., Dehpour, A. R., & Rahimian, R. (2015). Therapeutic potential of cannabinoids in counteracting chemotherapy-induced adverse effects: An exploratory review. Phytotherapy Research, 29(3), 332-338. https://doi.org/10.1002/ptr.5265
Piccolo, J., & Kolesar, J. M. (2014). Prevention and treatment of chemotherapy-induced peripheral neuropathy. American Journal of Health-System Pharmacy, 71(1), 19-25. https://doi.org/10.2146/ajhp130126
Rahimi, R., Amin, G., & Ardekani, M. R. S. (2012). A review on Citrullus colocynthis Schrad.: From traditional Iranian medicine to modern phytotherapy. The Journal of Alternative and Complementary Medicine., 18(6), 551-554. https://doi.org/10.1089/acm.2011.0297
Salehi, Z., & Roayaei, M. (2015). Effect of vitamin E on oxaliplatin-induced peripheral neuropathy prevention: A randomized controlled trial. International journal of preventive medicine, 6.
Schloss, J., Colosimo, M., & Vitetta, L. (2017). Herbal medicines and chemotherapy induced peripheral neuropathy (CIPN): A critical literature review. Critical Reviews in Food Science and Nutrition, 57(6), 1107-1118. https://doi.org/10.1080/10408398.2014.889081
Shahriari-Ahmadi, A., Fahimi, A., Payandeh, M., & Sadeghi, M. (2015). Prevalence of oxaliplatin-induced chronic neuropathy and influencing factors in patients with colorectal cancer in Iran. Asian Pacific Journal of Cancer Prevention, 16(17), 7603-7606. https://doi.org/10.7314/APJCP.2015.16.17.7603
Shakeri, A., Hashempur, M. H., Mojibian, M., Aliasl, F., Bioos, S., & Nejatbakhsh, F. (2018). A comparative study of ranitidine and quince (Cydonia oblonga mill) sauce on gastroesophageal reflux disease (GERD) in pregnancy: A randomised, open-label, active-controlled clinical trial. Journal of Obstetrics and Gynaecology, 38(7), 899-905. https://doi.org/10.1080/01443615.2018.1431210
Shidfar, F., Rajab, A., Rahideh, T., Khandouzi, N., Hosseini, S., & Shidfar, S. (2015). The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes. Journal of Complementary & Integrative Medicine., 12(2), 165-170. https://doi.org/10.1515/jcim-2014-0021
Tariq, A., Sadia, S., Pan, K., Ullah, I., Mussarat, S., Sun, F., … Adnan, M. (2017). A systematic review on ethnomedicines of anti-cancer plants. Phytotherapy Research, 31(2), 202-264. https://doi.org/10.1002/ptr.5751