Tyrosine-protein phosphatase non-receptor type 2 inhibits alveolar bone resorption in diabetic periodontitis via dephosphorylating CSF1 receptor.
Alveolar Bone Loss
/ drug therapy
Animals
Calcifediol
/ chemistry
Cells, Cultured
Cytokines
/ metabolism
Diabetes Mellitus, Experimental
/ complications
Fibroblasts
/ enzymology
Gingiva
/ cytology
Inflammation
/ genetics
Male
Mice
Mice, Inbred C57BL
Periodontitis
/ drug therapy
Porphyromonas gingivalis
Protein Tyrosine Phosphatase, Non-Receptor Type 2
/ genetics
RNA, Small Interfering
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
/ metabolism
Tyrosine
/ metabolism
25(OH)2D3
CSF1R
alveolar bone resorption
diabetic periodontitis
tyrosine-protein phosphatase non-receptor type 2
Journal
Journal of cellular and molecular medicine
ISSN: 1582-4934
Titre abrégé: J Cell Mol Med
Pays: England
ID NLM: 101083777
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
16
02
2019
revised:
12
06
2019
accepted:
28
06
2019
pubmed:
3
8
2019
medline:
26
9
2020
entrez:
3
8
2019
Statut:
ppublish
Résumé
Tyrosine-protein phosphatase non-receptor type 2 (PTPN2) is an important protection factor for diabetes and periodontitis, but the underlying mechanism remains elusive. This study aimed to identify the substrate of PTPN2 in mediating beneficial effects of 25-Hydroxyvitamin D
Identifiants
pubmed: 31373168
doi: 10.1111/jcmm.14545
pmc: PMC6787442
doi:
Substances chimiques
Csf1r protein, mouse
0
Cytokines
0
RNA, Small Interfering
0
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
0
Tyrosine
42HK56048U
Protein Tyrosine Phosphatase, Non-Receptor Type 2
EC 3.1.3.48
Ptpn2 protein, mouse
EC 3.1.3.48
Calcifediol
P6YZ13C99Q
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6690-6699Informations de copyright
© 2019 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.
Références
Nature. 2003 May 15;423(6937):337-42
pubmed: 12748652
J Periodontol. 2013 Apr;84(4 Suppl):S153-69
pubmed: 23631575
J Periodontol. 2013 Oct;84(10):1401-8
pubmed: 23136946
Clin Microbiol Rev. 2000 Oct;13(4):547-58
pubmed: 11023956
PLoS One. 2016 Sep 09;11(9):e0162724
pubmed: 27611995
Cancer Cell. 2008 Aug 12;14(2):166-79
pubmed: 18691551
Biochem Biophys Res Commun. 2002 Oct 4;297(4):811-7
pubmed: 12359225
Diabetes Res Clin Pract. 2007 Jul;77(1):47-57
pubmed: 17112620
Med Clin (Barc). 2015 Jul 6;145(1):31-5
pubmed: 25192582
Curr Biol. 2002 Mar 19;12(6):446-53
pubmed: 11909529
Arthritis Rheum. 2012 Mar;64(3):752-61
pubmed: 21968903
J Clin Periodontol. 2008 Sep;35(8 Suppl):398-409
pubmed: 18724865
Acta Odontol Scand. 2014 May;72(4):265-73
pubmed: 23931568
J Cell Mol Med. 2019 Oct;23(10):6690-6699
pubmed: 31373168
PLoS One. 2014 Jun 24;9(6):e100838
pubmed: 24959715
Cell. 1998 Apr 17;93(2):165-76
pubmed: 9568710
Endocrinol Metab Clin North Am. 2017 Dec;46(4):845-870
pubmed: 29080639
J Biol Chem. 2012 Apr 20;287(17):13694-704
pubmed: 22375015
Nat Rev Immunol. 2015 Jan;15(1):30-44
pubmed: 25534621
Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3597-602
pubmed: 9520411
Mol Cell Biol. 2013 Feb;33(3):557-70
pubmed: 23166300
J Cell Biochem. 2003 Mar 1;88(4):695-705
pubmed: 12577303
Oral Health Prev Dent. 2009;7(2):107-27
pubmed: 19583037
J Investig Med. 2011 Aug;59(6):881-6
pubmed: 21527855
Bone. 2007 Feb;40(2):251-64
pubmed: 17098490
Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6
pubmed: 23754342
Steroids. 2013 Feb;78(2):115-20
pubmed: 23138030
Mol Endocrinol. 2002 Jan;16(1):58-69
pubmed: 11773439
Mol Cell Biol. 2006 Jun;26(11):4149-60
pubmed: 16705167