Clinical utility of estimation of glomerular filtration rate in dogs.
canine
diagnosis
iohexol clearance
renal
Journal
Journal of veterinary internal medicine
ISSN: 1939-1676
Titre abrégé: J Vet Intern Med
Pays: United States
ID NLM: 8708660
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
30
01
2019
accepted:
01
07
2019
pubmed:
3
8
2019
medline:
22
10
2020
entrez:
3
8
2019
Statut:
ppublish
Résumé
Glomerular filtration rate (GFR) estimation is the gold standard for assessment of renal function, although the clinical utility of this test is unclear. To describe the clinical utility of GFR estimation in dogs. Medical records of 132 dogs that had serum iohexol clearance measured between 2012 and 2017. Iohexol clearance and clinical records were reviewed and submitting practices contacted to obtain outcome data. Dogs were classified into 4 groups based on the reason for performing GFR estimation: A1 (screening for pre-azotemic chronic kidney disease [CKD], n = 105), A2 (confirmation of azotemic CKD, n = 3), B (screening for pre-azotemic acute kidney injury, n = 19), and C (miscellaneous causes, n = 5). Descriptive review of the clinical utility of GFR estimation is provided. For dogs in Group A1, renal disease was diagnosed in 9/9 dogs with a GFR ≥40% decreased below the mean GFR of their body weight category, in 5/6 dogs with a ≥30% but <40% reduction in GFR and in 7/9 dogs with a ≥20% but <30% reduction in GFR. Glomerular filtration rate estimation is useful for the diagnosis of CKD before the onset of azotemia.
Sections du résumé
BACKGROUND
BACKGROUND
Glomerular filtration rate (GFR) estimation is the gold standard for assessment of renal function, although the clinical utility of this test is unclear.
OBJECTIVES
OBJECTIVE
To describe the clinical utility of GFR estimation in dogs.
ANIMALS
METHODS
Medical records of 132 dogs that had serum iohexol clearance measured between 2012 and 2017.
METHODS
METHODS
Iohexol clearance and clinical records were reviewed and submitting practices contacted to obtain outcome data. Dogs were classified into 4 groups based on the reason for performing GFR estimation: A1 (screening for pre-azotemic chronic kidney disease [CKD], n = 105), A2 (confirmation of azotemic CKD, n = 3), B (screening for pre-azotemic acute kidney injury, n = 19), and C (miscellaneous causes, n = 5). Descriptive review of the clinical utility of GFR estimation is provided.
RESULTS
RESULTS
For dogs in Group A1, renal disease was diagnosed in 9/9 dogs with a GFR ≥40% decreased below the mean GFR of their body weight category, in 5/6 dogs with a ≥30% but <40% reduction in GFR and in 7/9 dogs with a ≥20% but <30% reduction in GFR.
CONCLUSIONS AND CLINICAL IMPORTANCE
CONCLUSIONS
Glomerular filtration rate estimation is useful for the diagnosis of CKD before the onset of azotemia.
Identifiants
pubmed: 31373414
doi: 10.1111/jvim.15561
pmc: PMC6979109
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
195-205Informations de copyright
© 2019 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
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