Advancing clinical neuroscience through enhanced tools: Pediatric social anxiety as an example.
adolescent
anxiety
ecological momentary assessment
neuroimaging
social phobia
Journal
Depression and anxiety
ISSN: 1520-6394
Titre abrégé: Depress Anxiety
Pays: United States
ID NLM: 9708816
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
21
12
2018
revised:
02
05
2019
accepted:
05
06
2019
entrez:
3
8
2019
pubmed:
3
8
2019
medline:
1
2
2020
Statut:
ppublish
Résumé
Clinical researchers face challenges when trying to quantify diverse processes engaged during social interactions. We report results from two studies, each demonstrating the potential utility of tools for examining processes engaged during social interactions. In the first study, youth (n = 57) used a smartphone-based tool to rate mood and responses to social events. A subset (n = 20) completed the second, functional magnetic resonance imaging study. This second study related anxiety to error-evoked brain responses in two social conditions-while being observed and when alone. We also combined these tools to bridge clinical, social-contextual, and neural levels of measurement. Results from the first study showed an association between negatively-perceived social experiences and a range of negative emotions. In the second study there was a positive correlation during error monitoring between social-anxiety severity and context-specific activation of the pregenual anterior cingulate cortex. Finally, during imaging, the perceived quality of peer interactions as assessed using the smartphone-based tool, interacted with social context to predict levels of activation in the hippocampus and superior frontal gyrus. By improving measurement, enhanced tools may provide new means for studying relationships among anxiety, brain function, and social interactions.
Sections du résumé
BACKGROUND
Clinical researchers face challenges when trying to quantify diverse processes engaged during social interactions. We report results from two studies, each demonstrating the potential utility of tools for examining processes engaged during social interactions.
METHOD
In the first study, youth (n = 57) used a smartphone-based tool to rate mood and responses to social events. A subset (n = 20) completed the second, functional magnetic resonance imaging study. This second study related anxiety to error-evoked brain responses in two social conditions-while being observed and when alone. We also combined these tools to bridge clinical, social-contextual, and neural levels of measurement.
RESULTS
Results from the first study showed an association between negatively-perceived social experiences and a range of negative emotions. In the second study there was a positive correlation during error monitoring between social-anxiety severity and context-specific activation of the pregenual anterior cingulate cortex. Finally, during imaging, the perceived quality of peer interactions as assessed using the smartphone-based tool, interacted with social context to predict levels of activation in the hippocampus and superior frontal gyrus.
CONCLUSIONS
By improving measurement, enhanced tools may provide new means for studying relationships among anxiety, brain function, and social interactions.
Identifiants
pubmed: 31373756
doi: 10.1002/da.22937
pmc: PMC9589399
mid: NIHMS1742062
doi:
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
701-711Subventions
Organisme : Intramural NIH HHS
ID : Z99 MH999999
Pays : United States
Informations de copyright
© 2019 Wiley Periodicals, Inc.
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