Unique and specific Proteobacteria diversity in urinary microbiota of tolerant kidney transplanted recipients.
Adult
Biodiversity
Biomarkers
/ urine
Case-Control Studies
Female
Follow-Up Studies
Graft Rejection
/ etiology
Graft Survival
/ immunology
Humans
Immune Tolerance
/ immunology
Kidney Transplantation
/ adverse effects
Male
Middle Aged
Prognosis
Proteobacteria
/ classification
RNA, Ribosomal, 16S
/ genetics
Risk Factors
clinical research/practice
immunosuppression/immune modulation
kidney transplantation/nephrology
microbiomics
tolerance
translational research/science
Journal
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
21
03
2019
revised:
15
07
2019
accepted:
19
07
2019
pubmed:
3
8
2019
medline:
12
1
2021
entrez:
3
8
2019
Statut:
ppublish
Résumé
Host-microbiota interactions can modulate the immune system both at local and systemic levels, with potential consequences for organ transplantation outcomes. In this study, we hypothesized that differences in the urinary microbiome following kidney transplantation would be associated with posttransplantation status: stable, minimally immunosuppressed, or tolerant. One hundred thirteen urine samples from stable (n = 51), minimally immunosuppressed (n = 19), and spontaneously tolerant (n = 16) patients, paired with age-matched controls (n = 27) were profiled and compared to each other at a taxonomic level with special interest in the immunosuppressive regimen. All comparisons and correlations were adjusted on sex and time posttransplantation. Our results highlighted a unique and specific urinary microbiota associated with spontaneous tolerance characterized by a high diversity and a clear Proteobacteria profile. Finally, we report that this profile is (1) impacted by gender, (2) inversely correlated with immunosuppressive drugs (calcineurin inhibitors and mammalian target of rapamycin inhibitors), and (3) stable in time.
Identifiants
pubmed: 31374143
doi: 10.1111/ajt.15549
pii: S1600-6135(22)10050-X
doi:
Substances chimiques
Biomarkers
0
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
145-158Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL148672
Pays : United States
Investigateurs
Gilles Blancho
(G)
Julien Branchereau
(J)
Diego Cantarovich
(D)
Anne Cesbron
(A)
Agnès Chapelet
(A)
Jacques Dantal
(J)
Florent Delbos
(F)
Clément Deltombe
(C)
Anne Devis
(A)
Lucile Figueres
(L)
Claire Garandeau
(C)
Caroline Gourraud-Vercel
(C)
Maryvonne Hourmant
(M)
Christine Kandell
(C)
Georges Karam
(G)
Clarisse Kerleau
(C)
Aurélie Meurette
(A)
Anne Moreau
(A)
Karine Renaudin
(K)
Simon Ville
(S)
Alexandre Walencik
(A)
Informations de copyright
© 2019 The American Society of Transplantation and the American Society of Transplant Surgeons.
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