Defining Adult Stem Cell Function at Its Simplest: The Ability to Replace Lost Cells through Mitosis.
adult stem cell
cell division
neutral competition
plasticity
potential stem cell
quiescence
self-renewal
tissue maintenance
Journal
Cell stem cell
ISSN: 1875-9777
Titre abrégé: Cell Stem Cell
Pays: United States
ID NLM: 101311472
Informations de publication
Date de publication:
01 08 2019
01 08 2019
Historique:
entrez:
3
8
2019
pubmed:
3
8
2019
medline:
15
8
2020
Statut:
ppublish
Résumé
Classic studies on hematopoiesis indicate that blood cell numbers are maintained by rare, hard-wired, transplantable stem cells (SCs). Subsequent studies in other organs have implicitly assumed that all SC hierarchies follow the design of the hematopoietic system. Lineage tracing techniques have revolutionized the study of solid tissue SCs. It thus appears that key characteristics of the hematopoietic SC hierarchy (rarity of SCs, specific marker expression, quiescence, asymmetric division, and unidirectional differentiation) are not generalizable to other tissues. In light of these insights, we offer a revised, generalizable definition of SC function: the ability to replace lost tissue through cell division.
Identifiants
pubmed: 31374197
pii: S1934-5909(19)30300-5
doi: 10.1016/j.stem.2019.07.002
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
174-183Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.