Pre-EDIT: A Randomized Feasibility Trial of Elastance-Directed Intrapleural Catheter or Talc Pleurodesis in Malignant Pleural Effusion.
elastance
malignant pleural effusion
nonexpansile lung
pleural manometry
trapped lung
unexpandable lung
Journal
Chest
ISSN: 1931-3543
Titre abrégé: Chest
Pays: United States
ID NLM: 0231335
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
16
04
2019
revised:
20
06
2019
accepted:
15
07
2019
pubmed:
3
8
2019
medline:
29
5
2020
entrez:
3
8
2019
Statut:
ppublish
Résumé
Talc slurry pleurodesis (TSP) prevents recurrence of symptomatic malignant pleural effusion (MPE) in 71% to 78% patients. Nonexpansile lung (NEL) frequently accounts for TSP failure but is often occult predrainage, impairing selection of patients. NEL is associated with high pleural elastance (P Patients with symptomatic MPE were randomized 1:1 between EDIT and standard care (TSP). EDIT involved P Thirty-one patients were randomized (one allocation failure) over 12 months. P A phase 3 trial testing the effect of EDIT management on symptomatic MPE recurrence following TSP is feasible. ClinicalTrials.gov; No.: NCT03319186; URL: www.clinicaltrials.gov.
Sections du résumé
BACKGROUND
Talc slurry pleurodesis (TSP) prevents recurrence of symptomatic malignant pleural effusion (MPE) in 71% to 78% patients. Nonexpansile lung (NEL) frequently accounts for TSP failure but is often occult predrainage, impairing selection of patients. NEL is associated with high pleural elastance (P
METHODS
Patients with symptomatic MPE were randomized 1:1 between EDIT and standard care (TSP). EDIT involved P
RESULTS
Thirty-one patients were randomized (one allocation failure) over 12 months. P
CONCLUSIONS
A phase 3 trial testing the effect of EDIT management on symptomatic MPE recurrence following TSP is feasible.
TRIAL REGISTRY
ClinicalTrials.gov; No.: NCT03319186; URL: www.clinicaltrials.gov.
Identifiants
pubmed: 31374208
pii: S0012-3692(19)31384-4
doi: 10.1016/j.chest.2019.07.010
pii:
doi:
Substances chimiques
Talc
14807-96-6
Banques de données
ClinicalTrials.gov
['NCT03319186']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1204-1213Informations de copyright
Copyright © 2019 American College of Chest Physicians. All rights reserved.