Regulation of the chemotaxis histidine kinase CheA: A structural perspective.
Enzymology
Histidine kinase
Membrane proteins
Phosphorelay
Protein structure
Signal transduction
Journal
Biochimica et biophysica acta. Biomembranes
ISSN: 1879-2642
Titre abrégé: Biochim Biophys Acta Biomembr
Pays: Netherlands
ID NLM: 101731713
Informations de publication
Date de publication:
01 01 2020
01 01 2020
Historique:
received:
30
04
2019
revised:
24
07
2019
accepted:
25
07
2019
pubmed:
3
8
2019
medline:
28
4
2020
entrez:
3
8
2019
Statut:
ppublish
Résumé
Bacteria sense and respond to their environment through a highly conserved assembly of transmembrane chemoreceptors (MCPs), the histidine kinase CheA, and the coupling protein CheW, hereafter termed "the chemosensory array". In recent years, great strides have been made in understanding the architecture of the chemosensory array and how this assembly engenders sensitive and cooperative responses. Nonetheless, a central outstanding question surrounds how receptors modulate the activity of the CheA kinase, the enzymatic output of the sensory system. With a focus on recent advances, we summarize the current understanding of array structure and function to comment on the molecular mechanism by which CheA, receptors and CheW generate the high sensitivity, gain and dynamic range emblematic of bacterial chemotaxis. The complexity of the chemosensory arrays has motivated investigation with many different approaches. In particular, structural methods, genetics, cellular activity assays, nanodisc technology and cryo-electron tomography have provided advances that bridge length scales and connect molecular mechanism to cellular function. Given the high degree of component integration in the chemosensory arrays, we ultimately aim to understand how such networked molecular interactions generate a whole that is truly greater than the sum of its parts. This article is part of a Special Issue entitled: Molecular biophysics of membranes and membrane proteins.
Identifiants
pubmed: 31374212
pii: S0005-2736(19)30176-2
doi: 10.1016/j.bbamem.2019.183030
pmc: PMC7212787
mid: NIHMS1584058
pii:
doi:
Substances chimiques
Bacterial Proteins
0
Escherichia coli Proteins
0
Methyl-Accepting Chemotaxis Proteins
0
Histidine Kinase
EC 2.7.13.1
cheA protein, E coli
EC 2.7.13.3
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
183030Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM122535
Pays : United States
Informations de copyright
Copyright © 2019. Published by Elsevier B.V.
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