Cellular mechanisms of hereditary photoreceptor degeneration - Focus on cGMP.
Apoptosis
Necroptosis
PARthanatos
PKG
Raman microscopy
cGMP
Journal
Progress in retinal and eye research
ISSN: 1873-1635
Titre abrégé: Prog Retin Eye Res
Pays: England
ID NLM: 9431859
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
23
02
2019
revised:
25
07
2019
accepted:
29
07
2019
pubmed:
3
8
2019
medline:
4
2
2021
entrez:
3
8
2019
Statut:
ppublish
Résumé
The cellular mechanisms underlying hereditary photoreceptor degeneration are still poorly understood, a problem that is exacerbated by the enormous genetic heterogeneity of this disease group. However, the last decade has yielded a wealth of new knowledge on degenerative pathways and their diversity. Notably, a central role of cGMP-signalling has surfaced for photoreceptor cell death triggered by a subset of disease-causing mutations. In this review, we examine key aspects relevant for photoreceptor degeneration of hereditary origin. The topics covered include energy metabolism, epigenetics, protein quality control, as well as cGMP- and Ca
Identifiants
pubmed: 31374251
pii: S1350-9462(19)30014-X
doi: 10.1016/j.preteyeres.2019.07.005
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100772Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.