Conversion of Chitin to Defined Chitosan Oligomers: Current Status and Future Prospects.
chitin
chitosan
chitosan oligomers
deacetylation
depolymerization
design of experiments
enzymatic conversion
Journal
Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729
Informations de publication
Date de publication:
01 Aug 2019
01 Aug 2019
Historique:
received:
09
07
2019
revised:
25
07
2019
accepted:
26
07
2019
entrez:
4
8
2019
pubmed:
4
8
2019
medline:
21
1
2020
Statut:
epublish
Résumé
Chitin is an abundant polysaccharide primarily produced as an industrial waste stream during the processing of crustaceans. Despite the limited applications of chitin, there is interest from the medical, agrochemical, food and cosmetic industries because it can be converted into chitosan and partially acetylated chitosan oligomers (COS). These molecules have various useful properties, including antimicrobial and anti-inflammatory activities. The chemical production of COS is environmentally hazardous and it is difficult to control the degree of polymerization and acetylation. These issues can be addressed by using specific enzymes, particularly chitinases, chitosanases and chitin deacetylases, which yield better-defined chitosan and COS mixtures. In this review, we summarize recent chemical and enzymatic approaches for the production of chitosan and COS. We also discuss a design-of-experiments approach for process optimization that could help to enhance enzymatic processes in terms of product yield and product characteristics. This may allow the production of novel COS structures with unique functional properties to further expand the applications of these diverse bioactive molecules.
Identifiants
pubmed: 31374920
pii: md17080452
doi: 10.3390/md17080452
pmc: PMC6723438
pii:
doi:
Substances chimiques
Industrial Waste
0
Chitin
1398-61-4
Chitosan
9012-76-4
Glycoside Hydrolases
EC 3.2.1.-
chitosanase
EC 3.2.1.132
Chitinases
EC 3.2.1.14
Amidohydrolases
EC 3.5.-
chitin deacetylase
EC 3.5.1.41
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):625-9
pubmed: 8421697
Carbohydr Res. 2001 Jun 4;332(3):305-16
pubmed: 11376610
Int J Biol Macromol. 2018 Sep;116:931-938
pubmed: 29782982
Int J Biol Macromol. 2017 Mar;96:334-339
pubmed: 27965127
Bioresour Technol. 2016 Nov;220:200-207
pubmed: 27567481
J Am Chem Soc. 2019 Feb 20;141(7):3137-3145
pubmed: 30673279
J Agric Food Chem. 2002 Mar 27;50(7):1876-82
pubmed: 11902927
Int J Mol Sci. 2010;11(12):5152-64
pubmed: 21614199
Biomed Res Int. 2015;2015:857639
pubmed: 26273652
Appl Microbiol Biotechnol. 2015 Nov;99(22):9835-46
pubmed: 26227412
Mar Drugs. 2010 Jan 14;8(1):24-46
pubmed: 20161969
Bioprocess Biosyst Eng. 2015 Dec;38(12):2477-86
pubmed: 26470707
Sci Rep. 2016 Mar 18;6:23371
pubmed: 26988402
J Agric Food Chem. 2001 Oct;49(10):4845-51
pubmed: 11600033
Biochem Biophys Res Commun. 1974 May 7;58(1):13-9
pubmed: 4831061
Biotechnol Bioeng. 1997 Dec 20;56(6):610-7
pubmed: 18642332
Carbohydr Res. 2011 Aug 16;346(11):1307-10
pubmed: 21601835
Appl Environ Microbiol. 2016 Oct 27;82(22):6645-6655
pubmed: 27590819
Mar Drugs. 2016 Jul 23;14(8):
pubmed: 27455287
Microb Biotechnol. 2009 Mar;2(2):186-201
pubmed: 21261913
Int J Biol Macromol. 2015 Aug;79:167-73
pubmed: 25910648
Biomacromolecules. 2001 Fall;2(3):765-72
pubmed: 11710030
Trends Biotechnol. 2000 Jul;18(7):305-12
pubmed: 10856926
Sci Rep. 2017 Dec 18;7(1):17692
pubmed: 29255209
Materials (Basel). 2011 Aug 12;4(8):1399-1416
pubmed: 28824150
Molecules. 2012 Apr 17;17(4):4604-11
pubmed: 22510609
J Biotechnol. 2017 Mar 20;246:16-23
pubmed: 28219736
Food Chem. 2018 Jul 1;253:139-147
pubmed: 29502814
Biomed Mater. 2018 Jan 30;13(2):025009
pubmed: 29182521
Biochem Biophys Res Commun. 1974 Feb 4;56(3):669-75
pubmed: 4826874
Carbohydr Polym. 2015 Nov 5;132:304-10
pubmed: 26256353
Crit Rev Biotechnol. 2015 Mar;35(1):44-61
pubmed: 24083454
Mar Drugs. 2017 Feb 15;15(2):
pubmed: 28212295
Carbohydr Res. 2009 Apr 21;344(6):815-9
pubmed: 19254792
J Agric Food Chem. 2018 Feb 21;66(7):1658-1669
pubmed: 29359934
Protein Expr Purif. 2008 May;59(1):127-37
pubmed: 18314348
Biosci Biotechnol Biochem. 2017 Mar;81(3):547-550
pubmed: 27832730
Eur J Biochem. 1999 May;261(3):698-705
pubmed: 10215886
Biomacromolecules. 2003 Sep-Oct;4(5):1380-5
pubmed: 12959609
Carbohydr Polym. 2018 Nov 1;199:445-460
pubmed: 30143150
Mar Drugs. 2017 Dec 13;15(12):
pubmed: 29236064
Food Microbiol. 2008 Oct;25(7):922-8
pubmed: 18721683
Mar Drugs. 2012 Dec;10(12):2661-75
pubmed: 23342389
Biomed Res Int. 2014;2014:169071
pubmed: 24551839
Mar Drugs. 2015 Aug 14;13(8):5156-86
pubmed: 26287217
Polymers (Basel). 2018 Jan 26;10(2):
pubmed: 30966154
Int J Biol Macromol. 2017 Jun;99:465-476
pubmed: 28267611
Curr Opin Struct Biol. 2018 Feb;48:110-116
pubmed: 29207314
Sci Rep. 2014 Aug 22;4:6162
pubmed: 25145331
Mar Drugs. 2010 Mar 30;8(4):968-87
pubmed: 20479963
Curr Opin Struct Biol. 2005 Aug;15(4):447-52
pubmed: 16006119
Mar Drugs. 2010 May 28;8(6):1763-8
pubmed: 20631868
Yeast. 1997 Mar 30;13(4):327-36
pubmed: 9133736
Trends Biotechnol. 2001 Jan;19(1):13-4
pubmed: 11146097
Sci Rep. 2015 Mar 03;5:8716
pubmed: 25732514
J Vis Exp. 2014 Jan 31;(83):e51216
pubmed: 24514765
Carbohydr Polym. 2017 Oct 15;174:1121-1128
pubmed: 28821036
Bioresour Technol. 2015 Dec;198:503-9
pubmed: 26432054
Crit Rev Biotechnol. 2017 Feb;37(1):11-25
pubmed: 26526199
J Basic Microbiol. 2018 Oct;58(10):836-847
pubmed: 30022499
Carbohydr Polym. 2018 Mar 1;183:1-10
pubmed: 29352863
PLoS One. 2014 Aug 12;9(8):e104620
pubmed: 25117009
Carbohydr Polym. 2015 May 5;121:1-9
pubmed: 25659665
Mar Drugs. 2013 Mar 11;11(3):747-74
pubmed: 23478485
Pharmacol Ther. 2017 Feb;170:80-97
pubmed: 27773783
J Mol Biol. 1978 Apr 5;120(2):167-81
pubmed: 642008
Biotechnol Lett. 2016 Dec;38(12):2007-2014
pubmed: 27623794
Int J Biol Macromol. 2016 Aug;89:725-36
pubmed: 27151671
Crit Rev Food Sci Nutr. 2003;43(1):61-87
pubmed: 12587986
Int J Mol Sci. 2011;12(3):1936-63
pubmed: 21673932
Mar Drugs. 2015 Mar 02;13(3):1133-74
pubmed: 25738328
Enzyme Microb Technol. 2000 Apr 1;26(7):473-483
pubmed: 10771049
Int J Biol Macromol. 2017 Mar;96:324-333
pubmed: 27889343
J Funct Biomater. 2015 Mar 13;6(1):104-42
pubmed: 25780874
Biomacromolecules. 2008 Jul;9(7):1731-8
pubmed: 18547106
Glycobiology. 2007 Dec;17(12):1377-87
pubmed: 17884842
Biotechnol Prog. 2008 Nov-Dec;24(6):1191-203
pubmed: 19194932
Biochim Biophys Acta. 1961 Aug 5;51:283-94
pubmed: 13888803
FEMS Microbiol Lett. 2008 Dec;289(2):130-7
pubmed: 19054103
Appl Biochem Biotechnol. 2010 Oct;162(3):843-54
pubmed: 19760058
Plant Pathol J. 2016 Jun;32(3):242-50
pubmed: 27298599
Curr Microbiol. 2012 Dec;65(6):666-72
pubmed: 22922773
Angew Chem Int Ed Engl. 2014 Jul 1;53(27):6882-7
pubmed: 24810719
Front Microbiol. 2013 Jun 14;4:149
pubmed: 23785358
PLoS One. 2017 Nov 6;12(11):e0187544
pubmed: 29107991
Biochim Biophys Acta. 1965 Jul 1;101(2):193-200
pubmed: 5852519
Carbohydr Polym. 2018 Apr 15;186:420-428
pubmed: 29456005
Biochemistry. 2000 Aug 1;39(30):8837-43
pubmed: 10913295
J Food Sci Technol. 2012 Dec;49(6):695-703
pubmed: 24293688
Bioresour Technol. 2013 Jan;127:407-14
pubmed: 23138063
Int J Food Microbiol. 2002 Mar 25;74(1-2):65-72
pubmed: 11929171
Polymers (Basel). 2018 Mar 22;10(4):
pubmed: 30966387
3 Biotech. 2013 Feb;3(1):1-9
pubmed: 28324347
Sci Rep. 2017 Jan 17;7:40807
pubmed: 28094342
Sci Rep. 2018 Feb 1;8(1):2170
pubmed: 29391415
Int J Mol Sci. 2011 Jan 06;12(1):266-77
pubmed: 21339986
Mar Drugs. 2010 Sep 15;8(9):2493-516
pubmed: 20948902
J Chem Technol Biotechnol. 1994 Jun;60(2):133-40
pubmed: 7764962
Nat Struct Biol. 1996 Jul;3(7):638-48
pubmed: 8673609
Protein Expr Purif. 2002 Feb;24(1):111-6
pubmed: 11812231
Mar Drugs. 2010 Apr 27;8(5):1482-517
pubmed: 20559485
Int J Pharm. 2010 May 31;391(1-2):260-6
pubmed: 20170716
Polymers (Basel). 2018 Feb 22;10(2):
pubmed: 30966249
Nucleic Acids Res. 2014 Jan;42(Database issue):D490-5
pubmed: 24270786
Sci Rep. 2016 Nov 30;6:38018
pubmed: 27901067