Apolipoprotein A-I (ApoA-I), Immunity, Inflammation and Cancer.

HDL apolipoprotein A-I cancer immunity inflammation review

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
01 Aug 2019
Historique:
received: 20 06 2019
revised: 25 07 2019
accepted: 30 07 2019
entrez: 4 8 2019
pubmed: 4 8 2019
medline: 4 8 2019
Statut: epublish

Résumé

Apolipoprotein A-I (ApoA-I), the major protein component of high-density lipoproteins (HDL) is a multifunctional protein, involved in cholesterol traffic and inflammatory and immune response regulation. Many studies revealing alterations of ApoA-I during the development and progression of various types of cancer suggest that serum ApoA-I levels may represent a useful biomarker contributing to better estimation of cancer risk, early cancer diagnosis, follow up, and prognosis stratification of cancer patients. In addition, recent in vitro and animal studies disclose a more direct, tumor suppressive role of ApoA-I in cancer pathogenesis, which involves anti-inflammatory and immune-modulatory mechanisms. Herein, we review recent epidemiologic, clinicopathologic, and mechanistic studies investigating the role of ApoA-I in cancer biology, which suggest that enhancing the tumor suppressive activity of ApoA-I may contribute to better cancer prevention and treatment.

Identifiants

pubmed: 31374929
pii: cancers11081097
doi: 10.3390/cancers11081097
pmc: PMC6721368
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Subventions

Organisme : Human Resources Development, Education and Lifelong Learning, European Social Fund, Greek national funds
ID : KA 10071

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Konstantina Georgila (K)

Department of Biology, Medical School, University of Crete, Heraklion, Voutes, 71110 Crete, Greece.
Department of Pathology, Medical School, University of Crete, Heraklion, Voutes, 71110 Crete, Greece.

Dimitra Vyrla (D)

Department of Biology, Medical School, University of Crete, Heraklion, Voutes, 71110 Crete, Greece.
Department of Pathology, Medical School, University of Crete, Heraklion, Voutes, 71110 Crete, Greece.

Elias Drakos (E)

Department of Pathology, Medical School, University of Crete, Heraklion, Voutes, 71110 Crete, Greece. drakil@uoc.gr.

Classifications MeSH