Can medicines development improve outcomes in asthma and chronic obstructive pulmonary disease management by driving effectiveness?
Asthma
Chronic obstructive pulmonary disease (COPD)
Disease management
Effectiveness
Medicines development
Outcomes
Respiratory
Salford Lung Studies
Journal
Respiratory research
ISSN: 1465-993X
Titre abrégé: Respir Res
Pays: England
ID NLM: 101090633
Informations de publication
Date de publication:
02 Aug 2019
02 Aug 2019
Historique:
received:
14
01
2019
accepted:
08
07
2019
entrez:
4
8
2019
pubmed:
4
8
2019
medline:
29
1
2020
Statut:
epublish
Résumé
Despite the availability of treatment guidelines and inhaled medications for asthma and chronic obstructive pulmonary disease (COPD), much remains to be done to lessen the burden of these respiratory diseases for patients. The challenge of selecting effective and efficacious drugs for patients is a key focus area for healthcare professionals. Here we discuss the concept of "drivers of effectiveness"- features of a medicine which may increase or decrease its effectiveness in the presence of real-world factors - and highlight the importance of considering these drivers in the early stages of drug development, and exploring their impact in carefully designed pragmatic trials. Using the Salford Lung Studies (SLS) in asthma and COPD as an illustrative example, we discuss various features of the inhaled corticosteroid/long-acting β
Identifiants
pubmed: 31375102
doi: 10.1186/s12931-019-1127-6
pii: 10.1186/s12931-019-1127-6
pmc: PMC6679431
doi:
Substances chimiques
Anti-Asthmatic Agents
0
Types de publication
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
173Subventions
Organisme : GlaxoSmithKline plc
ID : N/A
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