Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade.
Animals
B7-H1 Antigen
/ antagonists & inhibitors
Bone Marrow Transplantation
/ methods
CTLA-4 Antigen
/ antagonists & inhibitors
Cell Line, Tumor
Combined Modality Therapy
Female
Homeostasis
Humans
Immunocompromised Host
/ drug effects
Immunotherapy
Male
Mice
Neoplasms
/ immunology
T-Lymphocytes
/ metabolism
Treatment Outcome
Xenograft Model Antitumor Assays
Journal
Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
03
04
2019
revised:
18
06
2019
accepted:
16
07
2019
pubmed:
4
8
2019
medline:
22
8
2020
entrez:
4
8
2019
Statut:
ppublish
Résumé
T-cell transfer into lymphodepleted recipients induces homeostatic activation and potentiates antitumor efficacy. In contrast to canonical T-cell receptor-induced activation, homeostatic activation yields a distinct phenotype and memory state whose regulatory mechanisms are poorly understood. Here, we show in patients and murine models that, following transfer into lymphodepleted bone marrow transplant (BMT) recipients, CD8
Identifiants
pubmed: 31375522
pii: 2159-8290.CD-19-0391
doi: 10.1158/2159-8290.CD-19-0391
pmc: PMC6825548
mid: NIHMS1535585
doi:
Substances chimiques
B7-H1 Antigen
0
CD274 protein, human
0
CTLA-4 Antigen
0
CTLA4 protein, human
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1520-1537Subventions
Organisme : NCI NIH HHS
ID : R01 CA154947
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA190400
Pays : United States
Organisme : NCI NIH HHS
ID : R00 CA140728
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007605
Pays : United States
Organisme : Damon Runyon Cancer Research Foundation
ID : CI-76-14
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA196521
Pays : United States
Organisme : NICHD NIH HHS
ID : R21 HD091461
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI078892
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
©2019 American Association for Cancer Research.
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