Role of Major Toxin Virulence Factors in Pertussis Infection and Disease Pathogenesis.
Adenylate cyclase toxin-hemolysin
Bordetella toxins
Pertussis pathogenesis
Pertussis toxin
Tracheal Cytotoxin
Journal
Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103
Informations de publication
Date de publication:
2019
2019
Historique:
pubmed:
4
8
2019
medline:
7
2
2020
entrez:
4
8
2019
Statut:
ppublish
Résumé
Bordetella pertussis produces several toxins that affect host-pathogen interactions. Of these, the major toxins that contribute to pertussis infection and disease are pertussis toxin, adenylate cyclase toxin-hemolysin and tracheal cytotoxin. Pertussis toxin is a multi-subunit protein toxin that inhibits host G protein-coupled receptor signaling, causing a wide array of effects on the host. Adenylate cyclase toxin-hemolysin is a single polypeptide, containing an adenylate cyclase enzymatic domain coupled to a hemolysin domain, that primarily targets phagocytic cells to inhibit their antibacterial activities. Tracheal cytotoxin is a fragment of peptidoglycan released by B. pertussis that elicits damaging inflammatory responses in host cells. This chapter describes these three virulence factors of B. pertussis, summarizing background information and focusing on the role of each toxin in infection and disease pathogenesis, as well as their role in pertussis vaccination.
Identifiants
pubmed: 31376138
doi: 10.1007/5584_2019_403
pmc: PMC7038575
mid: NIHMS1553661
doi:
Substances chimiques
Adenylate Cyclase Toxin
0
Bacterial Toxins
0
Hemolysin Proteins
0
Virulence Factors
0
Virulence Factors, Bordetella
0
Pertussis Toxin
EC 2.4.2.31
Adenylyl Cyclases
EC 4.6.1.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
35-51Subventions
Organisme : NIAID NIH HHS
ID : R01 AI141372
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI135465
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI137778
Pays : United States
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