Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D).
CSNK1D
Cancer
Casein kinase 1
Hedgehog pathway
N
P
Phosphorylation
R
S
Site-specific phosphorylation
Small molecule inhibitor
Stress-induced kinase
Wnt signaling pathway
p53
Journal
Gene
ISSN: 1879-0038
Titre abrégé: Gene
Pays: Netherlands
ID NLM: 7706761
Informations de publication
Date de publication:
05 Oct 2019
05 Oct 2019
Historique:
received:
30
04
2019
revised:
19
07
2019
accepted:
23
07
2019
pubmed:
4
8
2019
medline:
28
8
2019
entrez:
4
8
2019
Statut:
ppublish
Résumé
Members of the highly conserved pleiotropic CK1 family of serine/threonine-specific kinases are tightly regulated in the cell and play crucial regulatory roles in multiple cellular processes from protozoa to human. Since their dysregulation as well as mutations within their coding regions contribute to the development of various different pathologies, including cancer and neurodegenerative diseases, they have become interesting new drug targets within the last decade. However, to develop optimized CK1 isoform-specific therapeutics in personalized therapy concepts, a detailed knowledge of the regulation and functions of the different CK1 isoforms, their various splice variants and orthologs is mandatory. In this review we will focus on the stress-induced CK1 isoform delta (CK1δ), thereby addressing its regulation, physiological functions, the consequences of its deregulation for the development and progression of diseases, and its potential as therapeutic drug target.
Identifiants
pubmed: 31376410
pii: S0378-1119(19)30664-X
doi: 10.1016/j.gene.2019.144005
pmc: PMC7939460
mid: NIHMS1569684
pii:
doi:
Substances chimiques
Isoenzymes
0
Neoplasm Proteins
0
Casein Kinase Idelta
EC 2.7.11.1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
144005Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM089820
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
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