Genetic risk for Alzheimer's disease and functional brain connectivity in children and adolescents.
Adolescent
Alzheimer Disease
/ diagnostic imaging
Brain
/ diagnostic imaging
Brazil
/ epidemiology
Child
Cross-Sectional Studies
Female
Functional Neuroimaging
/ methods
Genetic Predisposition to Disease
/ epidemiology
Humans
Male
Nerve Net
/ diagnostic imaging
Polymorphism, Single Nucleotide
/ genetics
Alzheimer's disease
Functional connectivity
Polygenic risk score
Tau protein
Journal
Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
20
02
2019
revised:
22
06
2019
accepted:
30
06
2019
pubmed:
4
8
2019
medline:
26
6
2020
entrez:
4
8
2019
Statut:
ppublish
Résumé
Research suggested accumulation of tau proteins might lead to the degeneration of functional networks. Studies investigating the impact of genetic risk for Alzheimer's disease (AD) on early brain connections might shed light on mechanisms leading to AD development later in life. Here, we aim to investigate whether the polygenic risk score for Alzheimer's disease (AD-PRS) influences the connectivity among regions susceptible to tau pathology during childhood and adolescence. Participants were youth, aged 6-14 years, and recruited in Porto Alegre (discovery sample, n = 332) and São Paulo (replication sample, n = 304), Brazil. Subjects underwent genotyping and 6-min resting state funcional magnetic resonance imaging. Connections between the local maxima of tau pathology networks were used as dependent variables. The AD-PRS was associated with the connectivity between the right precuneus and the right superior temporal gyrus (discovery sample: β = 0.180, p
Identifiants
pubmed: 31376729
pii: S0197-4580(19)30193-9
doi: 10.1016/j.neurobiolaging.2019.06.011
pmc: PMC7658444
mid: NIHMS1641822
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
10-17Subventions
Organisme : Intramural NIH HHS
ID : ZIA MH002781
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
Références
Nat Genet. 2013 Dec;45(12):1452-8
pubmed: 24162737
Br J Psychol. 2004 Feb;95(Pt 1):57-79
pubmed: 15005868
Dev Sci. 2005 Nov;8(6):525-34
pubmed: 16246244
Bioinformatics. 2015 May 1;31(9):1466-8
pubmed: 25550326
Nat Genet. 2018 May;50(5):668-681
pubmed: 29700475
JAMA Psychiatry. 2019 May 1;76(5):516-525
pubmed: 30698613
Alzheimers Dement (Amst). 2017 Apr 18;8:73-85
pubmed: 28560308
Neurology. 2016 Aug 2;87(5):481-8
pubmed: 27385740
Neurology. 2014 Mar 4;82(9):752-60
pubmed: 24523481
Am J Psychiatry. 2018 Jun 1;175(6):555-563
pubmed: 29495896
Ann Neurol. 2012 Oct;72(4):571-7
pubmed: 23109152
Curr Alzheimer Res. 2014 Mar;11(3):274-82
pubmed: 24484280
J Zhejiang Univ Sci B. 2018 Dec.;19(12):924-934
pubmed: 30507076
Neuroimage. 2012 Feb 1;59(3):2142-54
pubmed: 22019881
Neuroimage. 2013 Aug 1;76:183-201
pubmed: 23499792
J Alzheimers Dis. 2018;61(4):1575-1587
pubmed: 29376852
Acta Neuropathol. 2011 Feb;121(2):171-81
pubmed: 21170538
J Abnorm Psychol. 2017 Jan;126(1):137-148
pubmed: 27748619
Neuron. 2009 Apr 16;62(1):42-52
pubmed: 19376066
Int J Methods Psychiatr Res. 2015 Mar;24(1):58-73
pubmed: 25469819
Nature. 2014 Jul 24;511(7510):421-7
pubmed: 25056061
Front Neurosci. 2017 Mar 31;11:167
pubmed: 28408865
J Neural Transm (Vienna). 2008;115(2):261-8
pubmed: 17994184
JAMA Neurol. 2014 Jan;71(1):11-22
pubmed: 24276092
Neuroimage. 2015 Jan 1;104:44-51
pubmed: 25290886
J Neuropathol Exp Neurol. 2011 Nov;70(11):960-9
pubmed: 22002422
Sci Rep. 2015 Oct 06;5:14824
pubmed: 26439278
Cereb Cortex. 2016 Feb;26(2):695-707
pubmed: 25405944
Genome Res. 2009 Sep;19(9):1655-64
pubmed: 19648217
Brain. 2018 Feb 1;141(2):568-581
pubmed: 29315361
Brain Imaging Behav. 2017 Jun;11(3):818-828
pubmed: 27189159
Nature. 2006 Oct 19;443(7113):768-73
pubmed: 17051202
Nat Rev Neurol. 2015 Feb;11(2):69-70
pubmed: 25623789