Lipid peroxidation in neurodegeneration.
Biological sample
Biomarker
Blood
Lipid peroxidation
Neurodegeneration
Journal
Clinica chimica acta; international journal of clinical chemistry
ISSN: 1873-3492
Titre abrégé: Clin Chim Acta
Pays: Netherlands
ID NLM: 1302422
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
14
05
2019
revised:
30
07
2019
accepted:
31
07
2019
pubmed:
5
8
2019
medline:
12
2
2020
entrez:
5
8
2019
Statut:
ppublish
Résumé
Neurodegenerative diseases have great social and economic impact and cause millions of deaths every year. The potential molecular mechanisms in these pathologies have been widely studied and implicate lipid peroxidation as an important factor in the development of neurodegenerative disorders such as Alzheimer's, Parkinson's and Huntington's diseases. Data indicates that pathologic mechanisms specifically involve ferroptosis and mitochondrial dysfunction. Here we review the molecular mechanisms related to the lipid peroxidation that involve the development of neurodegeneration, as well as the utility of some biomarkers in diagnosis, prognosis and evaluation of new therapies for neurodegenerative diseases.
Identifiants
pubmed: 31377127
pii: S0009-8981(19)31987-4
doi: 10.1016/j.cca.2019.07.037
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
178-188Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.