Relationship between albuminuric CKD and diabetic retinopathy in a real-world setting of type 2 diabetes: Findings from No blind study.
Aged
Albuminuria
/ diagnosis
Cross-Sectional Studies
Diabetes Mellitus, Type 2
/ diagnosis
Diabetic Nephropathies
/ diagnosis
Diabetic Retinopathy
/ diagnosis
Female
Glomerular Filtration Rate
Humans
Italy
/ epidemiology
Kidney
/ physiopathology
Male
Middle Aged
Renal Elimination
Renal Insufficiency, Chronic
/ diagnosis
Risk Factors
Severity of Illness Index
Albumin excretion rate
Diabetic kidney disease
Diabetic retinopathy
Glomerular filtration rate
Journal
Nutrition, metabolism, and cardiovascular diseases : NMCD
ISSN: 1590-3729
Titre abrégé: Nutr Metab Cardiovasc Dis
Pays: Netherlands
ID NLM: 9111474
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
06
04
2019
revised:
02
05
2019
accepted:
20
05
2019
pubmed:
5
8
2019
medline:
3
3
2020
entrez:
5
8
2019
Statut:
ppublish
Résumé
Recently, the albuminocentric view of diabetic kidney disease (DKD) in type 2 diabetes (T2DM) has been changing. Therefore, the relationship between diabetic retinopathy (DR) and chronic kidney disease (CKD) has to be addressed according to this new clinical presentation of DKD. The aim of this study was to evaluate, in a real-world setting, the correlation DR-DKD in T2DM. A total of 2068 type 2 diabetic patients enrolled in a multicenter cross-sectional study were investigated. Albuminuric subjects were largely prevalent among subjects with DR (p = 0.019). In the whole study population, no difference in albumin excretion rate (AER) was observed between presence/absence of DR; instead, AER was significantly higher among patients with glomerular filtration rate (eGFR) < 60 mL/min/1.73 m In T2DM with DKD, the AER seems to be related to the presence of DR. This association is confirmed above all in those with more severe DR.
Sections du résumé
BACKGROUND AND AIMS
Recently, the albuminocentric view of diabetic kidney disease (DKD) in type 2 diabetes (T2DM) has been changing. Therefore, the relationship between diabetic retinopathy (DR) and chronic kidney disease (CKD) has to be addressed according to this new clinical presentation of DKD. The aim of this study was to evaluate, in a real-world setting, the correlation DR-DKD in T2DM.
METHODS AND RESULTS
A total of 2068 type 2 diabetic patients enrolled in a multicenter cross-sectional study were investigated. Albuminuric subjects were largely prevalent among subjects with DR (p = 0.019). In the whole study population, no difference in albumin excretion rate (AER) was observed between presence/absence of DR; instead, AER was significantly higher among patients with glomerular filtration rate (eGFR) < 60 mL/min/1.73 m
CONCLUSION
In T2DM with DKD, the AER seems to be related to the presence of DR. This association is confirmed above all in those with more severe DR.
Identifiants
pubmed: 31377186
pii: S0939-4753(19)30215-7
doi: 10.1016/j.numecd.2019.05.065
pii:
doi:
Types de publication
Comparative Study
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
923-930Investigateurs
D Giugliano
(D)
M I Maiorino
(MI)
G Riccardi
(G)
L Bozzetto
(L)
V Guardasole
(V)
R Di Palo
(R)
O Carbonara
(O)
M Riccio
(M)
G De Simone
(G)
L Lucibelli
(L)
S Masi
(S)
Informations de copyright
Copyright © 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.