Ugi efficient synthesis, biological evaluation and molecular docking of coumarin-quinoline hybrids as apoptotic agents through mitochondria-related pathways.
Antineoplastic Agents
/ chemical synthesis
Apoptosis
Benzopyrans
/ chemical synthesis
Coumarins
/ chemistry
Female
Humans
Membrane Potential, Mitochondrial
Mitochondria
/ drug effects
Molecular Docking Simulation
Ovarian Neoplasms
/ drug therapy
Quinolines
/ chemistry
Reactive Oxygen Species
/ metabolism
Tumor Cells, Cultured
Apoptosis
Bcl-2
Cancer
Coumarin-quinoline hybrids
Mitochondria-related pathways
Survivin
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
30
03
2019
revised:
20
07
2019
accepted:
22
07
2019
pubmed:
5
8
2019
medline:
21
10
2020
entrez:
5
8
2019
Statut:
ppublish
Résumé
Ugi reaction was a reliable procedure for the synthesis of new coumarin-quinoline frameworks. Excellent yields, mild reaction conditions and easily available and inexpensive starting materials are advantages of this protocol. Cytotoxic effects of fourteen products were investigated in A2780 human ovarian cancer cells. Two synthesized compounds (L11 and L12) exhibited more anti-cancer activity than other derivatives with IC
Identifiants
pubmed: 31377390
pii: S0045-2068(19)30496-1
doi: 10.1016/j.bioorg.2019.103147
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Benzopyrans
0
Coumarins
0
Quinolines
0
Reactive Oxygen Species
0
Types de publication
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103147Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.