Combinational drug-loaded lipid nanocapsules for the treatment of cancer.
Animals
Antineoplastic Agents
/ administration & dosage
Cell Line, Tumor
Drug Combinations
Erythrocytes
/ drug effects
Female
Hemolysis
/ drug effects
Humans
Irinotecan
/ administration & dosage
Lipids
/ administration & dosage
Mice, Inbred BALB C
Nanocapsules
/ administration & dosage
Neoplasms
/ drug therapy
Phenylurea Compounds
/ administration & dosage
Pyridines
/ administration & dosage
Colorectal cancer
Lipid nanocapsules
Regorafenib
SN38
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
05 Oct 2019
05 Oct 2019
Historique:
received:
26
06
2019
revised:
30
07
2019
accepted:
31
07
2019
pubmed:
5
8
2019
medline:
31
1
2020
entrez:
5
8
2019
Statut:
ppublish
Résumé
The purpose of this study was to investigate the feasibility of an intravenously administered combinational therapy using lipid nanocapsules (LNCs) as a drug delivery carrier for the treatment of different cancers. Therefore, we encapsulated 6 anticancer drugs within LNCs. Their size was approximately 50 nm. Except for oxaliplatin, their encapsulation efficiency, which was measured by different analytical methods, varied between 75% for SN38 to 100% for regorafenib. The in vitro studies showed a nonsignificant difference between the cytotoxicity of free and encapsulated drugs and a significant decrease in haemolysis by encapsulation in LNCs. Finally, the in vivo experiment showed that a combinational regimen of SN38-LNCs and regorafenib-LNCs abates CT26 murine colorectal cancer growth and increases median survival time.
Identifiants
pubmed: 31377406
pii: S0378-5173(19)30633-7
doi: 10.1016/j.ijpharm.2019.118588
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Drug Combinations
0
Lipids
0
Nanocapsules
0
Phenylurea Compounds
0
Pyridines
0
regorafenib
24T2A1DOYB
Irinotecan
7673326042
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
118588Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.