Neuropathological correlates of amyloid PET imaging in Down syndrome.
Alzheimer's disease
Down syndrome
amyloid
neuropathology
positron emission tomography
striatum
Journal
Developmental neurobiology
ISSN: 1932-846X
Titre abrégé: Dev Neurobiol
Pays: United States
ID NLM: 101300215
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
03
05
2019
revised:
31
07
2019
accepted:
31
07
2019
pubmed:
6
8
2019
medline:
28
3
2020
entrez:
6
8
2019
Statut:
ppublish
Résumé
Down syndrome (DS) results in an overproduction of amyloid-β (Aβ) peptide associated with early onset of Alzheimer's disease (AD). DS cases have Aβ deposits detectable histologically as young as 12-30 years of age, primarily in the form of diffuse plaques, the type of early amyloid pathology also seen at pre-clinical (i.e., pathological aging) and prodromal stages of sporadic late onset AD. In DS subjects aged >40 years, levels of cortical Aβ deposition are similar to those observed in late onset AD and in addition to diffuse plaques involve cored plaques associated with dystrophic neurites (neuritic plaques), which are of neuropathological diagnostic significance in AD. The purpose of this review is to summarize and discuss findings from amyloid PET imaging studies of DS in reference to postmortem amyloid-based neuropathology. PET neuroimaging applied to subjects with DS has the potential to (a) track the natural progression of brain pathology, including the earliest stages of amyloid accumulation, and (b) determine whether amyloid PET biomarkers predict the onset of dementia. In addition, the question that is still incompletely understood and relevant to both applications is the ability of amyloid PET to detect Aβ deposits in their earliest form.
Identifiants
pubmed: 31379087
doi: 10.1002/dneu.22713
pmc: PMC6892598
mid: NIHMS1044813
doi:
Substances chimiques
Amyloid beta-Peptides
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
750-766Subventions
Organisme : RRD VA
ID : I01 RX001778
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG015466
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG052528
Pays : United States
Organisme : RRD VA
ID : I01 RX000511
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG061566
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG016573
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG014449
Pays : United States
Organisme : RRD VA
ID : I01 RX000952
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG051406
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG025204
Pays : United States
Informations de copyright
© 2019 Wiley Periodicals, Inc.
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