Extended sequencing of vaccine and wild-type capripoxvirus isolates provides insights into genes modulating virulence and host range.
Africa
Animals
Asia
Biological Evolution
Capripoxvirus
/ genetics
Cells, Cultured
Genetic Speciation
Genetic Variation
Genome, Viral
/ genetics
Host Specificity
/ genetics
India
Male
Middle East
Mutation
Poxviridae Infections
/ prevention & control
Sheep
Sheep Diseases
/ prevention & control
Testis
/ virology
Viral Vaccines
/ immunology
Virulence
capripoxvirus
goatpox virus
lumpy skin disease virus
poxvirus
sheeppox virus
virulence
Journal
Transboundary and emerging diseases
ISSN: 1865-1682
Titre abrégé: Transbound Emerg Dis
Pays: Germany
ID NLM: 101319538
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
18
06
2019
revised:
22
07
2019
accepted:
30
07
2019
pubmed:
6
8
2019
medline:
18
4
2020
entrez:
6
8
2019
Statut:
ppublish
Résumé
The genus Capripoxvirus in the subfamily Chordopoxvirinae, family Poxviridae, comprises sheeppox virus (SPPV), goatpox virus (GTPV) and lumpy skin disease virus (LSDV), which cause the eponymous diseases across parts of Africa, the Middle East and Asia. These diseases cause significant economic losses and can have a devastating impact on the livelihoods and food security of small farm holders. So far, only live classically attenuated SPPV, GTPV and LSDV vaccines are commercially available and the history, safety and efficacy of many have not been well established. Here, we report 13 new capripoxvirus genome sequences, including the hairpin telomeres, from both pathogenic field isolates and vaccine strains. We have also updated the genome annotations to incorporate recent advances in our understanding of poxvirus biology. These new genomes and genes grouped phenetically with other previously sequenced capripoxvirus strains, and these new alignments collectively identified several recurring alterations in genes thought to modulate virulence and host range. In particular, some of the many large capripoxvirus ankyrin and kelch-like proteins are commonly mutated in vaccine strains, while the variola virus B22R-like gene homolog has also been disrupted in many vaccine isolates. Among these vaccine isolates, frameshift mutations are especially common and clearly present a risk of reversion to wild type in vaccines bearing these mutations. A consistent pattern of gene inactivation from LSDV to GTPV and then SPPV is also observed, much like the pattern of gene loss in orthopoxviruses, but, rather surprisingly, the overall genome size of ~150 kbp remains relatively constant. These data provide new insights into the evolution of capripoxviruses and the determinants of pathogenicity and host range. They will find application in the development of new vaccines with better safety, efficacy and trade profiles.
Substances chimiques
Viral Vaccines
0
Banques de données
GENBANK
['MN072619', 'MN072621', 'MN072620', 'MN072622', 'MN072625', 'MN072623', 'MN072624', 'MN072627', 'MN072626', 'MN072631', 'MN072630', 'MN072629', 'MN072628', 'AY243312', 'KT438550', 'KT438551', 'MG972412', 'KX764645', 'KX764644', 'KX764643', 'AF409138', 'MH64667', 'KY829023', 'KY702007', 'MH893760', 'KX894508', 'AF409137', 'KX683219', 'AF325528', 'KC951854', 'MH381810', 'AY077836', 'AY077835', 'KX576657', 'AY077834', 'AY077833', 'AY077832', 'KSGP0240', 'AWX92162.1']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
80-97Subventions
Organisme : Australian Biosecurity Cooperative Research Centre for Emerging Infectious Diseases
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : RGPIN 05201
Organisme : Canadian Institutes for Health Research
ID : PS 159614
Organisme : Canada Foundation for Innovation
Informations de copyright
© 2019 Her Majesty the Queen in Right of Canada Transboundary and Emerging Diseases © 2019 Blackwell Verlag GmbH.
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