Selective Acetogenins and Their Potential as Anticancer Agents.
acetogenins
apoptosis
autophagy
cell cycle
cell death
cytotoxicity
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2019
2019
Historique:
received:
10
01
2019
accepted:
17
06
2019
entrez:
6
8
2019
pubmed:
6
8
2019
medline:
6
8
2019
Statut:
epublish
Résumé
The Kingdom Plantae has provided several successful drugs for the treatment of different diseases, including cancer, and continues to be a source of new possible therapeutic molecules. For example, the annonaceous acetogenins (AAs) are secondary metabolites found in the Annonaceae family, which are plants employed in traditional medicine for the treatment of cancer and various other diseases. These polyketides are inhibitors of Complex I in the respiratory chain of tumor cells, a process that is closely related to tumor metabolism, cell death, apoptosis, and autophagy. The goal of this review is to update readers on the role of the AAs as antitumor agents using
Identifiants
pubmed: 31379567
doi: 10.3389/fphar.2019.00783
pmc: PMC6657400
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
783Références
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