Novel Peptide Conjugates of Modified Oligonucleotides for Inhibition of Bacterial RNase P.
antibacterial activity
bacterial RNase P
inhibition of RNase P
modified oligonucleotides
oligo(2’-O-methylribonucleotides)
penetration into bacterial cells
peptide conjugates of oligonucleotides
phosphoryl guanidine oligonucleotides
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2019
2019
Historique:
received:
15
03
2019
accepted:
24
06
2019
entrez:
6
8
2019
pubmed:
6
8
2019
medline:
6
8
2019
Statut:
epublish
Résumé
Novel alternatives to traditional antibiotics are now of great demand for the successful treatment of microbial infections. Here, we present the engineering and properties of new oligonucleotide inhibitors of RNase P, an essential bacterial enzyme. The series of 2'-
Identifiants
pubmed: 31379580
doi: 10.3389/fphar.2019.00813
pmc: PMC6658616
doi:
Types de publication
Journal Article
Langues
eng
Pagination
813Références
Cell Mol Life Sci. 2003 May;60(5):854-61
pubmed: 12827275
Chembiochem. 2003 Oct 6;4(10):1041-8
pubmed: 14523922
Chembiochem. 2003 Oct 6;4(10):1049-56
pubmed: 14523923
RNA. 2003 Dec;9(12):1437-45
pubmed: 14624000
J Biol Chem. 2006 Oct 13;281(41):30613-20
pubmed: 16901906
Chem Pharm Bull (Tokyo). 2007 Apr;55(4):685-7
pubmed: 17409574
J Am Chem Soc. 2007 Jul 4;129(26):8259-70
pubmed: 17559214
Bioconjug Chem. 2008 Apr;19(4):920-7
pubmed: 18376855
J Antimicrob Chemother. 2009 Feb;63(2):225-9
pubmed: 19004840
Mol Pharm. 2010 Aug 2;7(4):1260-5
pubmed: 20476763
Curr Drug Discov Technol. 2010 Jun;7(2):76-85
pubmed: 20836761
Philos Trans R Soc Lond B Biol Sci. 2011 Oct 27;366(1580):2936-41
pubmed: 21930585
Front Microbiol. 2011 Sep 12;2:185
pubmed: 21941522
PLoS One. 2013 Jul 29;8(7):e70108
pubmed: 23922923
Methods Mol Biol. 2014;1103:45-56
pubmed: 24318885
Science. 1989 Dec 22;246(4937):1578-84
pubmed: 2480641
Molecules. 2014 Jul 02;19(7):9228-39
pubmed: 24991756
Ther Adv Drug Saf. 2014 Dec;5(6):229-41
pubmed: 25436105
Surg Clin North Am. 2014 Dec;94(6):1195-218
pubmed: 25440119
Biochim Biophys Acta. 2015 Feb;1848(2):544-53
pubmed: 25445677
Acta Naturae. 2014 Oct;6(4):116-8
pubmed: 25558402
Ann N Y Acad Sci. 2015 Sep;1354:98-110
pubmed: 25866265
J Control Release. 2015 Jul 28;210:115-24
pubmed: 25980622
Biomolecules. 2015 Nov 09;5(4):3029-50
pubmed: 26569326
Biomolecules. 2016 May 13;6(2):null
pubmed: 27187488
Curr Genet. 2017 Dec;63(6):973-976
pubmed: 28497241
Biomed Pharmacother. 2017 Sep;93:580-588
pubmed: 28686972
Nanomedicine. 2018 Apr;14(3):745-758
pubmed: 29341934
Front Microbiol. 2018 Oct 08;9:2408
pubmed: 30349524
Eur J Pharm Biopharm. 2019 Jan;134:166-177
pubmed: 30468838
Chem Commun (Camb). 2019 Jan 15;55(6):763-766
pubmed: 30480264
Front Microbiol. 2018 Nov 26;9:2870
pubmed: 30534121
Mol Biol (Mosk). 2018 Nov-Dec;52(6):1045-1054
pubmed: 30633247
Sci Rep. 2019 Apr 19;9(1):6300
pubmed: 31004100
Cell. 1983 Dec;35(3 Pt 2):849-57
pubmed: 6197186