Prophylactic Treatment of Pediatric Migraine: Is There Anything New in the Last Decade?
guidelines
migraine
pediatric migraine
preventive
prophylactic drugs
therapy
treatment
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2019
2019
Historique:
received:
16
05
2019
accepted:
02
07
2019
entrez:
6
8
2019
pubmed:
6
8
2019
medline:
6
8
2019
Statut:
epublish
Résumé
Migraine is a frequent and very disabling disease, especially at pediatric age. Despite this, there are few controlled data on the prophylactic treatment of primary headaches in this category of age. Given that the recently introduced calcitonin gene-related peptide (CGRP) inhibitors (CGRP-r) are still limited to adulthood, there is no drug with exclusive indication for migraine treatment in pediatric age. This raises several limitations in terms of adherence and effectiveness of the therapy. Moreover, the scenario is complicated by placebo response, which is larger in children and adolescents than in adults and often leads to an improvement in the attack frequency even in absence of any active pharmacological treatment. Our aim was to investigate the real evidence concerning the prophylactic therapy of pediatric migraine by reviewing the clinical studies published between 2010 and 2019.
Identifiants
pubmed: 31379721
doi: 10.3389/fneur.2019.00771
pmc: PMC6646427
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
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