Licorice: From Pseudohyperaldosteronism to Therapeutic Uses.
aldosterone
glycyrrhetinic acid (GA)
hypertension
inflammation
licorice
polycystic ovary syndrome (PCOS)
pseudohyperaldosteronism
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2019
2019
Historique:
received:
19
02
2019
accepted:
03
07
2019
entrez:
6
8
2019
pubmed:
6
8
2019
medline:
6
8
2019
Statut:
epublish
Résumé
Licorice has been used as a medicinal plant from 2.500 years. It shows a wide range of biological and pharmacological activities, including anti-inflammatory and immune regulatory actions. One of its most known effects is the induction of hypertension, and it can induce what appears to be pseudohyperaldosteronism, due to glycyrrhetinic acid, the main active component of the root. Glycyrrhetinic acid and metabolites block the 11 beta-hydroxysteroid dehydrogenase type 2 and also bind mineralocorticoid receptors directly, acting as agonists. However, other interesting therapeutic uses of licorice are linked to its anti-androgen and estrogen-like activity, especially in the treatment of polycystic ovary syndrome (PCOS) in conjunction with spironolactone therapy. In this brief review, we report the main features and possible therapeutic uses of this ancient plant.
Identifiants
pubmed: 31379750
doi: 10.3389/fendo.2019.00484
pmc: PMC6657287
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
484Références
N Engl J Med. 1999 Sep 2;341(10):709-17
pubmed: 10471456
N Engl J Med. 1999 Oct 7;341(15):1158
pubmed: 10515764
Adv Physiol Educ. 2002 Dec;26(1-4):8-20
pubmed: 11850323
Exp Clin Endocrinol Diabetes. 2002 Sep;110(6):257-61
pubmed: 12373628
N Engl J Med. 2003 Apr 3;348(14):1309-21
pubmed: 12668699
Clin Endocrinol (Oxf). 2003 Jul;59(1):143-4
pubmed: 12807517
Lancet. 1953 Apr 4;1(6762):657-63
pubmed: 13036119
Am J Proctol. 1953 Sep;4(3):229-30
pubmed: 13080458
J Clin Endocrinol Metab. 2004 Apr;89(4):1973-6
pubmed: 15070972
Steroids. 2004 Oct-Nov;69(11-12):763-6
pubmed: 15579328
Steroids. 2005 Jul;70(8):538-42
pubmed: 15894038
J Ethnopharmacol. 2005 Jul 14;99(3):317-24
pubmed: 15978760
Hypertension. 2005 Aug;46(2):313-20
pubmed: 15998706
Eur J Obstet Gynecol Reprod Biol. 2007 Mar;131(1):61-67
pubmed: 17113210
Phytother Res. 2008 Feb;22(2):141-8
pubmed: 17886224
J Clin Hypertens (Greenwich). 2008 Feb;10(2):153-7
pubmed: 18256580
Arch Biochem Biophys. 2008 Nov 1;479(1):46-51
pubmed: 18778682
Ned Tijdschr Geneeskd. 1946 Feb 16-23;90(7-8):135-7
pubmed: 20291620
J Endocrinol Invest. 1990 Nov;13(10):847-8
pubmed: 2096161
J Endocrinol. 2012 Apr;213(1):15-24
pubmed: 22159507
Eur J Endocrinol. 2012 Apr;166(4):703-10
pubmed: 22223702
Steroids. 2012 May;77(6):655-8
pubmed: 22387621
Hypertension. 2012 Aug;60(2):e9
pubmed: 22733466
J Clin Endocrinol Metab. 2013 Jun;98(6):2494-501
pubmed: 23539731
Indian J Exp Biol. 2013 Feb;51(2):129-38
pubmed: 23923606
Expert Opin Pharmacother. 2014 May;15(7):909-12
pubmed: 24617854
J Endocrinol Invest. 1989 May;12(5):303-6
pubmed: 2549114
Steroids. 2016 Jan;105:42-9
pubmed: 26631549
G Ital Nefrol. 2016 Feb;33 Suppl 66:33.S66.12
pubmed: 26913880
J Endocrinol Invest. 2016 Sep;39(9):1015-21
pubmed: 27072668
Food Nutr Res. 2016 Apr 22;60:30830
pubmed: 27113136
Am J Transl Res. 2016 Feb 15;8(2):314-28
pubmed: 27158328
Acta Pol Pharm. 2016 Mar-Apr;73(2):517-27
pubmed: 27180445
High Blood Press Cardiovasc Prev. 2016 Sep;23(3):231-5
pubmed: 27251484
Expert Opin Pharmacother. 2016 Sep;17(13):1713-5
pubmed: 27450358
Am J Physiol. 1989 Aug;257(2 Pt 1):E170-4
pubmed: 2764099
Endocrinol Jpn. 1988 Apr;35(2):333-42
pubmed: 2850159
Clin Endocrinol (Oxf). 2017 Nov;87(5):500-507
pubmed: 28590513
Phytother Res. 2017 Sep;31(9):1330-1340
pubmed: 28685911
Am J Physiol. 1987 Apr;252(4 Pt 1):E505-8
pubmed: 2952017
Reumatologia. 2018;56(2):87-91
pubmed: 29853723
Ophthalmol Retina. 2019 Feb;3(2):154-160
pubmed: 31014765
Am J Physiol. 1985 Mar;248(3 Pt 1):E388-90
pubmed: 3156509
JAMA. 1968 Aug 12;205(7):492-6
pubmed: 5695305
Clin Endocrinol (Oxf). 1983 Nov;19(5):609-12
pubmed: 6315264
N Z Med J. 1995 Apr 26;108(998):156-7
pubmed: 7761058
Diabetes Care. 1994 Nov;17(11):1356
pubmed: 7821181
J Endocrinol Invest. 1996 Oct;19(9):624-9
pubmed: 8957748
Endocr Rev. 1997 Feb;18(1):135-56
pubmed: 9034789
Annu Rev Physiol. 1997;59:365-93
pubmed: 9074769