Sonic Hedgehog Is a Determinant of γδ T-Cell Differentiation in the Thymus.
Hedgehog
Shh
Smoothened
thymus
γδ T-cell
γδNKT
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
22
01
2019
accepted:
01
07
2019
entrez:
6
8
2019
pubmed:
6
8
2019
medline:
23
10
2020
Statut:
epublish
Résumé
Here we investigate the function of Hedgehog (Hh) signaling in thymic γδ T-cell maturation and subset differentiation. Analysis of Hh mutants showed that Hh signaling promotes γδ T-cell development in the thymus and influences γδ T-cell effector subset distribution. Hh-mediated transcription in thymic γδ cells increased γδ T-cell number, and promoted their maturation and increased the γδNKT subset, whereas inhibition of Hh-mediated transcription reduced the thymic γδ T-cell population and increased expression of many genes that are normally down-regulated during γδ T-cell maturation. These changes were also evident in spleen, where increased Hh signaling increased γδNKT cells, but reduced CD27-CD44+ and Vγ2+ populations. Systemic
Identifiants
pubmed: 31379834
doi: 10.3389/fimmu.2019.01629
pmc: PMC6658896
doi:
Substances chimiques
Hedgehog Proteins
0
Shh protein, mouse
0
Smo protein, mouse
0
Smoothened Receptor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1629Subventions
Organisme : Medical Research Council
ID : MR/P000843/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
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