Understanding the association of polycystic ovary syndrome and non-alcoholic fatty liver disease.
Cytokeratin-18
Hyperandrogenism
Insulin resistance
Ninein
Obesity
Sex hormone-binding globulin
Journal
The Journal of steroid biochemistry and molecular biology
ISSN: 1879-1220
Titre abrégé: J Steroid Biochem Mol Biol
Pays: England
ID NLM: 9015483
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
09
04
2019
revised:
25
07
2019
accepted:
28
07
2019
pubmed:
6
8
2019
medline:
15
1
2020
entrez:
6
8
2019
Statut:
ppublish
Résumé
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among reproductive-age women. Patients with non-alcoholic fatty liver disease (NAFLD) often suffer from metabolic syndrome, atherosclerosis, ischemic heart disease, and extrahepatic tumors, conferring a lower survival than the general population; therefore it is crucial to study the association between NAFLD and PCOS since it remains poorly understood. Insulin resistance (IR) plays a central role in the pathogenesis of NAFLD and PCOS; also, hyperandrogenism enhances IR in these patients. IR, present in the NAFLD-PCOS association could decrease the hepatic production of sex hormone-binding globulin through a possible regulation mediated by hepatocyte nuclear factor 4 alpha. On the other hand, apoptotic processes initiated by androgens actively contribute to the progression of NAFLD. Considering the association between the two conditions, the screening of women with PCOS for the presence of NAFLD appears reasonable. The pathophysiological mechanisms of PCOS-NAFLD association and the initial approach will be reviewed here.
Identifiants
pubmed: 31381969
pii: S0960-0760(19)30214-6
doi: 10.1016/j.jsbmb.2019.105445
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
105445Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.