SOX9 in cartilage development and disease.
Journal
Current opinion in cell biology
ISSN: 1879-0410
Titre abrégé: Curr Opin Cell Biol
Pays: England
ID NLM: 8913428
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
30
06
2019
accepted:
06
07
2019
pubmed:
6
8
2019
medline:
15
4
2020
entrez:
6
8
2019
Statut:
ppublish
Résumé
SOX9 is a pivotal transcription factor in chondrocytes, a lineage essential in skeletogenesis. Its mandatory role in transactivating many cartilage-specific genes is well established, whereas its pioneer role in lineage specification, which along with transactivation defines master transcription factors, remains to be better defined. Abundant, but yet incomplete evidence exists that intricate molecular networks control SOX9 activity during the multi-step chondrogenesis pathway. They include a highly modular genetic regulation, post-transcriptional and post-translational modifications, and varying sets of functional partners. Fully uncovering SOX9 actions and regulation is fundamental to explain mechanisms underlying many diseases that directly or indirectly affect SOX9 activities and to design effective disease treatments. We here review current knowledge, highlight recent discoveries, and propose new research directions to answer remaining questions.
Identifiants
pubmed: 31382142
pii: S0955-0674(19)30044-4
doi: 10.1016/j.ceb.2019.07.008
pmc: PMC6956855
mid: NIHMS1534366
pii:
doi:
Substances chimiques
SOX9 Transcription Factor
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
39-47Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR068308
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR072649
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
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