Short Term Results of Fibrin Gel Obtained from Cord Blood Units: A Preliminary in Vitro Study.
TGF-β1
cord blood units
fibrin gel
platelet rich plasma
platelets
proteomic analysis
Journal
Bioengineering (Basel, Switzerland)
ISSN: 2306-5354
Titre abrégé: Bioengineering (Basel)
Pays: Switzerland
ID NLM: 101676056
Informations de publication
Date de publication:
02 Aug 2019
02 Aug 2019
Historique:
received:
20
06
2019
revised:
28
07
2019
accepted:
31
07
2019
entrez:
7
8
2019
pubmed:
7
8
2019
medline:
7
8
2019
Statut:
epublish
Résumé
Recent findings have shown that the fibrin gel derived from cord blood units (CBUs) play a significant role in wound healing and tissue regeneration. The aim of this study was to standardize the fibrin gel production process in order to allow for its regular use. CBUs ( The results of this study showed that high volume CBUs were characterized by greater recovery rates, concentration and number of PLTs compared to the low volume CBUs. Proteomic analysis revealed the presence of key proteins for regenerative medicine. Fibrin gel was successfully produced from CBUs of all groups. In this study, low volume CBUs could be an alternative source for the production of fibrin gel, which can be used in multiple regenerative medicine approaches.
Sections du résumé
BACKGROUND
BACKGROUND
Recent findings have shown that the fibrin gel derived from cord blood units (CBUs) play a significant role in wound healing and tissue regeneration. The aim of this study was to standardize the fibrin gel production process in order to allow for its regular use.
METHODS
METHODS
CBUs (
RESULTS
RESULTS
The results of this study showed that high volume CBUs were characterized by greater recovery rates, concentration and number of PLTs compared to the low volume CBUs. Proteomic analysis revealed the presence of key proteins for regenerative medicine. Fibrin gel was successfully produced from CBUs of all groups.
CONCLUSION
CONCLUSIONS
In this study, low volume CBUs could be an alternative source for the production of fibrin gel, which can be used in multiple regenerative medicine approaches.
Identifiants
pubmed: 31382445
pii: bioengineering6030066
doi: 10.3390/bioengineering6030066
pmc: PMC6783834
pii:
doi:
Types de publication
Journal Article
Langues
eng
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