A Galactoside-Binding Protein Tricked into Binding Unnatural Pyranose Derivatives: 3-Deoxy-3-Methyl-Gulosides Selectively Inhibit Galectin-1.
benzamide
fluorescence polarization
galectin-1
gulopyranosides
selective
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
02 Aug 2019
02 Aug 2019
Historique:
received:
23
06
2019
revised:
20
07
2019
accepted:
22
07
2019
entrez:
7
8
2019
pubmed:
7
8
2019
medline:
7
1
2020
Statut:
epublish
Résumé
Galectins are a family of galactoside-recognizing proteins involved in different galectin-subtype-specific inflammatory and tumor-promoting processes, which motivates the development of inhibitors that are more selective galectin inhibitors than natural ligand fragments. Here, we describe the synthesis and evaluation of 3-
Identifiants
pubmed: 31382488
pii: ijms20153786
doi: 10.3390/ijms20153786
pmc: PMC6696278
pii:
doi:
Substances chimiques
Galectin 1
0
Ligands
0
Methylglycosides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Vetenskapsrådet
ID : 621-2016-03667
Organisme : Knut och Alice Wallenbergs Stiftelse
ID : KAW 2013.0022
Organisme : Galecto Biotech AB
ID : -
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