Adhesive Cements That Bond Soft Tissue Ex Vivo.
bioceramic
biomaterial
bone cement
calcium phosphate
lap shear
phosphoserine
phosphoserine modified cement
self-setting
silicate
tissue adhesive
Journal
Materials (Basel, Switzerland)
ISSN: 1996-1944
Titre abrégé: Materials (Basel)
Pays: Switzerland
ID NLM: 101555929
Informations de publication
Date de publication:
03 Aug 2019
03 Aug 2019
Historique:
received:
31
05
2019
revised:
23
07
2019
accepted:
24
07
2019
entrez:
7
8
2019
pubmed:
7
8
2019
medline:
7
8
2019
Statut:
epublish
Résumé
The aim of the present study was to evaluate the soft tissue bond strength of a newly developed, monomeric, biomimetic, tissue adhesive called phosphoserine modified cement (PMC). Two types of PMCs were evaluated using lap shear strength (LSS) testing, on porcine skin: a calcium metasilicate (CS1), and alpha tricalcium phosphate (αTCP) PMC. CS1 PCM bonded strongly to skin, reaching a peak LSS of 84, 132, and 154 KPa after curing for 0.5, 1.5, and 4 h, respectively. Cyanoacrylate and fibrin glues reached an LSS of 207 kPa and 33 kPa, respectively. αTCP PMCs reached a final LSS of ≈110 kPa. In soft tissues, stronger bond strengths were obtained with αTCP PMCs containing large amounts of amino acid (70-90 mol%), in contrast to prior studies in calcified tissues (30-50 mol%). When αTCP particle size was reduced by wet milling, and for CS1 PMCs, the strongest bonding was obtained with mole ratios of 30-50% phosphoserine. While PM-CPCs behave like stiff ceramics after setting, they bond to soft tissues, and warrant further investigation as tissue adhesives, particularly at the interface between hard and soft tissues.
Identifiants
pubmed: 31382566
pii: ma12152473
doi: 10.3390/ma12152473
pmc: PMC6695630
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Stiftelsen för Strategisk Forskning
ID : RMA15-0110
Organisme : EIT Health Headstart Grant, Uppsala Sweden
ID : 2018 HS PoC 2018-HS-0046
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