Evaluation of the Influence of Process Parameters on the Properties of Resveratrol-Loaded NLC Using 2
factorial design
high shear homogenization
nanostructured lipid carriers (NLC)
resveratrol
ultrasound method
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
03 Aug 2019
03 Aug 2019
Historique:
received:
17
07
2019
revised:
28
07
2019
accepted:
30
07
2019
entrez:
7
8
2019
pubmed:
7
8
2019
medline:
7
8
2019
Statut:
epublish
Résumé
Resveratrol (RSV) is a natural antioxidant commonly found in grapes, berries, and nuts that has shown promising results in the treatment of a variety of degenerative and age-related diseases. Despite the proven beneficial results on reduction of reactive oxidant species (ROS) and on inflammatory process, RSV shows various limitations including low long-term stability, aqueous solubility, and bioavailability, restricting its applications in the medical-pharmaceutical area. To overcome these limitations, it has been applied in pharmaceutical formulations as nanostructured lipid carriers (NLC). Thus, the present study focuses on the optimization of the production process of NLC. NLC was produced by high shear homogenization (HSH) and ultrasound method (US) using Compritol
Identifiants
pubmed: 31382599
pii: antiox8080272
doi: 10.3390/antiox8080272
pmc: PMC6719996
pii:
doi:
Types de publication
Journal Article
Langues
eng
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