Periodontal Disease in Patients Receiving Dialysis.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
03 Aug 2019
Historique:
received: 09 06 2019
revised: 01 08 2019
accepted: 01 08 2019
entrez: 7 8 2019
pubmed: 7 8 2019
medline: 9 1 2020
Statut: epublish

Résumé

Chronic kidney disease (CKD) is characterized by kidney damage with proteinuria, hematuria, and progressive loss of kidney function. The final stage of CKD is known as end-stage renal disease, which usually indicates that approximately 90% of normal renal function is lost, and necessitates renal replacement therapy for survival. The most widespread renal replacement therapy is dialysis, which includes peritoneal dialysis (PD) and hemodialysis (HD). However, despite the development of novel medical instruments and agents, both dialysis procedures have complications and disadvantages, such as cardiovascular disease due to excessive blood fluid and infections caused by impaired immunity. Periodontal disease is chronic inflammation induced by various pathogens and its frequency and severity in patients undergoing dialysis are higher compared to those in healthy individuals. Therefore, several investigators have paid special attention to the impact of periodontal disease on inflammation-, nutrient-, and bone metabolism-related markers; the immune system; and complications in patients undergoing dialysis. Furthermore, the influence of diabetes on the prevalence and severity of manifestations of periodontal disease, and the properties of saliva in HD patients with periodontitis have been reported. Conversely, there are few reviews discussing periodontal disease in patients with dialysis. In this review, we discuss the available studies and review the pathological roles and clinical significance of periodontal disease in patients receiving PD or HD. In addition, this review underlines the importance of oral health and adequate periodontal treatment to maintain quality of life and prolong survival in these patients.

Identifiants

pubmed: 31382656
pii: ijms20153805
doi: 10.3390/ijms20153805
pmc: PMC6695931
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : KAKENHI
ID : 16K15690

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Auteurs

Yasuyoshi Miyata (Y)

Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan. yasu-myt@nagasaki-u.ac.jp.

Yoko Obata (Y)

Department of Nephrology, Nagasaki University Hospital, Nagasaki 852-8501, Japan.

Yasushi Mochizuki (Y)

Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan.
Division of Blood Purification, Nagasaki University Hospital, Nagasaki 852-8501, Japan.

Mineaki Kitamura (M)

Department of Nephrology, Nagasaki University Hospital, Nagasaki 852-8501, Japan.
Division of Blood Purification, Nagasaki University Hospital, Nagasaki 852-8501, Japan.

Kensuke Mitsunari (K)

Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan.

Tomohiro Matsuo (T)

Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan.

Kojiro Ohba (K)

Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan.

Hiroshi Mukae (H)

Department of Respiratory Medicine, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8591, Japan.

Tomoya Nishino (T)

Department of Nephrology, Nagasaki University Hospital, Nagasaki 852-8501, Japan.

Atsutoshi Yoshimura (A)

Department of Periodontology and Endodontology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan.

Hideki Sakai (H)

Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan.
Division of Blood Purification, Nagasaki University Hospital, Nagasaki 852-8501, Japan.

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